Phase II Study of Preoperative Helical Tomotherapy With a Simultaneous Integrated Boost for Rectal Cancer

Purpose The addition of concomitant chemotherapy to preoperative radiotherapy is considered the standard of care for patients with cT3–4 rectal cancer. The combined treatment modality increases the complete response rate and local control (LC), but has no impact on survival or the incidence of dista...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2012-05, Vol.83 (1), p.142-148
Hauptverfasser:	Engels, Benedikt, M.D, Tournel, Koen, M.Sc, Everaert, Hendrik, M.D., Ph.D, Hoorens, Anne, M.D., Ph.D, Sermeus, Alexandra, M.D, Christian, Nicolas, M.D., Ph.D, Storme, Guy, M.D., Ph.D, Verellen, Dirk, Ph.D, De Ridder, Mark, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - radiotherapy Adult Aged Aged, 80 and over Biological and medical sciences Chemoradiotherapy - adverse effects Chemoradiotherapy - methods CHEMOTHERAPY COMPUTERIZED TOMOGRAPHY CT-GUIDED RADIOTHERAPY Disease-Free Survival Dose Fractionation ENTERITIS Female Fluorouracil - therapeutic use Gastroenterology. Liver. Pancreas. Abdomen Helical tomotherapy Hematology, Oncology and Palliative Medicine Humans Image-guided radiotherapy Intestine, Small - diagnostic imaging Intestine, Small - pathology LYMPH NODES Male Medical sciences METASTASES Middle Aged NEOPLASMS NMR IMAGING PATIENTS Preoperative Care - methods Preoperative radiotherapy Prospective Studies RADIATION DOSES Radiation Injuries - complications Radiation Injuries - pathology Radiation-Sensitizing Agents - therapeutic use Radiography Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiotherapy, Image-Guided - methods Radiotherapy, Image-Guided - mortality Radiotherapy, Intensity-Modulated - adverse effects Radiotherapy, Intensity-Modulated - methods Radiotherapy, Intensity-Modulated - mortality Rectal cancer Rectal Neoplasms - drug therapy Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery RECTUM Rectum - pathology Rectum - radiation effects Remission Induction SIDE EFFECTS Simultaneous integrated boost Stomach. Duodenum. Small intestine. Colon. Rectum. Anus TOXICITY Treatment Outcome Tumors Urinary Bladder - diagnostic imaging Urinary Bladder - pathology
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