5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells

Natural flavonoids have diverse pharmacological activities, including anti-oxidative, anti-inflammatory, and anti-cancer activities. In this study, we investigated the molecular mechanism underlying the action of 5-methoxyflavanone (5-MF) which has a strong bioavailability and metabolic stability. O...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology and applied pharmacology 2011-08, Vol.254 (3), p.288-298
Hauptverfasser:	Shin, Soon Young, Hyun, Jiye, Yu, Jae-Ran, Lim, Yoongho, Lee, Young Han
Format:	Artikel
Sprache:	eng
Schlagworte:	5-methoxyflavanone 60 APPLIED LIFE SCIENCES APOPTOSIS Apoptosis - drug effects Apoptosis - physiology Autophagy Autophagy - drug effects Autophagy - physiology Biological and medical sciences BIOLOGICAL AVAILABILITY BODY Caspase CELL CYCLE Cell Cycle - drug effects Cell Cycle - physiology Cell Division - drug effects Cell Division - physiology Cell Survival - drug effects Cell Survival - physiology CHEMICAL REACTIONS CLEAVAGE DIGESTIVE SYSTEM DISEASES DNA damage checkpoint DNA DAMAGES Flavones - chemistry Flavones - toxicity FLAVONOIDS G2 Phase - drug effects G2 Phase - physiology Gastroenterology. Liver. Pancreas. Abdomen GASTROINTESTINAL TRACT HCT116 Cells Humans INFLAMMATION INHIBITION INTESTINES LARGE INTESTINE Medical sciences MICROSTRUCTURE NEOPLASMS ORGANIC COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANS OXIDATION PATHOLOGICAL CHANGES PHOSPHORYLATION SENSITIVITY Stomach. Duodenum. Small intestine. Colon. Rectum. Anus SYMPTOMS Toxicology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!