The effect of methylsulfonylmethane on the experimental colitis in the rat
Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables, has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur compound and a normal oxidative metabolite of dimethyl sulfoxide. This study was carried out to investigate the effect of...
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| Veröffentlicht in: | Toxicology and applied pharmacology 2011-06, Vol.253 (3), p.197-202 |
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| creator | Amirshahrokhi, K. Bohlooli, S. Chinifroush, M.M. |
| description | Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables, has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur compound and a normal oxidative metabolite of dimethyl sulfoxide. This study was carried out to investigate the effect of MSM in a rat model of experimental colitis. Colitis was induced by intracolonic instillation of 1ml of 5% of acetic acid. Rats were treated with MSM (400mg/kg/day, orally) for 4days. Animals were euthanized and distal colon evaluated histologically and biochemically. Tissue samples were used to measurement of malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), glutathione (GSH) and proinflammatory cytokine (TNF-α and IL-1β) levels. Results showed that MSM decreased macroscopic and microscopic colonic damage scores caused by administration of acetic acid. MSM treatment also significantly reduced colonic levels of MDA, MPO and IL-1β, while increased the levels of GSH and CAT compared with acetic acid-induced colitis group. It seems that MSM as a natural product may have a protective effect in an experimental ulcerative colitis.
► Methylsulfonylmethane occurs naturally in some green plants, fruits and vegetables. ► Methylsulfonylmethane (MSM) has anti-inflammatory and antioxidant effects. ► We evaluated the effects of MSM in a rat model of experimental ulcerative colitis. ► MSM has protective effect against acetic acid-induced colitis in rat. |
| doi_str_mv | 10.1016/j.taap.2011.03.017 |
| format | Article |
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► Methylsulfonylmethane occurs naturally in some green plants, fruits and vegetables. ► Methylsulfonylmethane (MSM) has anti-inflammatory and antioxidant effects. ► We evaluated the effects of MSM in a rat model of experimental ulcerative colitis. ► MSM has protective effect against acetic acid-induced colitis in rat.</description><identifier>ISSN: 0041-008X</identifier><identifier>EISSN: 1096-0333</identifier><identifier>DOI: 10.1016/j.taap.2011.03.017</identifier><identifier>PMID: 21463646</identifier><identifier>CODEN: TXAPA9</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; ACETIC ACID ; ANIMALS ; Anti-Inflammatory Agents - therapeutic use ; ANTIOXIDANTS ; Biological and medical sciences ; CARBOXYLIC ACIDS ; CATALASE ; Catalase - metabolism ; CHEMICAL REACTIONS ; Colitis - drug therapy ; Colitis - metabolism ; Colitis - pathology ; Dimethyl Sulfoxide - therapeutic use ; DMSO ; DRUGS ; ELEMENTS ; ENZYMES ; Experimental colitis ; FOOD ; FRUITS ; GLUTATHIONE ; Glutathione - analysis ; INFLAMMATION ; Interleukin-1beta - analysis ; Male ; Malondialdehyde - analysis ; MAMMALS ; Medical sciences ; METABOLITES ; Methylsulfonylmethane ; MONOCARBOXYLIC ACIDS ; NONMETALS ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC SULFUR COMPOUNDS ; OXIDATION ; OXIDOREDUCTASES ; OXYGEN ; PATHOLOGICAL CHANGES ; PEPTIDES ; Peroxidase - metabolism ; PEROXIDASES ; PLANTS ; POLYPEPTIDES ; PROTEINS ; RADIOPROTECTIVE SUBSTANCES ; RATS ; Rats, Wistar ; Reactive oxygen metabolites ; RESPONSE MODIFYING FACTORS ; RODENTS ; Sulfones - therapeutic use ; SULFOXIDES ; SYMPTOMS ; Toxicology ; Tumor Necrosis Factor-alpha - analysis ; VEGETABLES ; VERTEBRATES</subject><ispartof>Toxicology and applied pharmacology, 2011-06, Vol.253 (3), p.197-202</ispartof><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-9c4a8818d352b5e0c914e6551b6ff1f696a2e2bf53586177a4d591cb92f7056a3</citedby><cites>FETCH-LOGICAL-c445t-9c4a8818d352b5e0c914e6551b6ff1f696a2e2bf53586177a4d591cb92f7056a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.taap.2011.03.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24285074$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21463646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21587761$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Amirshahrokhi, K.</creatorcontrib><creatorcontrib>Bohlooli, S.</creatorcontrib><creatorcontrib>Chinifroush, M.M.</creatorcontrib><title>The effect of methylsulfonylmethane on the experimental colitis in the rat</title><title>Toxicology and applied pharmacology</title><addtitle>Toxicol Appl Pharmacol</addtitle><description>Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables, has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur compound and a normal oxidative metabolite of dimethyl sulfoxide. This study was carried out to investigate the effect of MSM in a rat model of experimental colitis. Colitis was induced by intracolonic instillation of 1ml of 5% of acetic acid. Rats were treated with MSM (400mg/kg/day, orally) for 4days. Animals were euthanized and distal colon evaluated histologically and biochemically. Tissue samples were used to measurement of malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), glutathione (GSH) and proinflammatory cytokine (TNF-α and IL-1β) levels. Results showed that MSM decreased macroscopic and microscopic colonic damage scores caused by administration of acetic acid. MSM treatment also significantly reduced colonic levels of MDA, MPO and IL-1β, while increased the levels of GSH and CAT compared with acetic acid-induced colitis group. It seems that MSM as a natural product may have a protective effect in an experimental ulcerative colitis.
► Methylsulfonylmethane occurs naturally in some green plants, fruits and vegetables. ► Methylsulfonylmethane (MSM) has anti-inflammatory and antioxidant effects. ► We evaluated the effects of MSM in a rat model of experimental ulcerative colitis. ► MSM has protective effect against acetic acid-induced colitis in rat.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>ACETIC ACID</subject><subject>ANIMALS</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>ANTIOXIDANTS</subject><subject>Biological and medical sciences</subject><subject>CARBOXYLIC ACIDS</subject><subject>CATALASE</subject><subject>Catalase - metabolism</subject><subject>CHEMICAL REACTIONS</subject><subject>Colitis - drug therapy</subject><subject>Colitis - metabolism</subject><subject>Colitis - pathology</subject><subject>Dimethyl Sulfoxide - therapeutic use</subject><subject>DMSO</subject><subject>DRUGS</subject><subject>ELEMENTS</subject><subject>ENZYMES</subject><subject>Experimental colitis</subject><subject>FOOD</subject><subject>FRUITS</subject><subject>GLUTATHIONE</subject><subject>Glutathione - analysis</subject><subject>INFLAMMATION</subject><subject>Interleukin-1beta - analysis</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>MAMMALS</subject><subject>Medical sciences</subject><subject>METABOLITES</subject><subject>Methylsulfonylmethane</subject><subject>MONOCARBOXYLIC ACIDS</subject><subject>NONMETALS</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC SULFUR COMPOUNDS</subject><subject>OXIDATION</subject><subject>OXIDOREDUCTASES</subject><subject>OXYGEN</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PEPTIDES</subject><subject>Peroxidase - metabolism</subject><subject>PEROXIDASES</subject><subject>PLANTS</subject><subject>POLYPEPTIDES</subject><subject>PROTEINS</subject><subject>RADIOPROTECTIVE SUBSTANCES</subject><subject>RATS</subject><subject>Rats, Wistar</subject><subject>Reactive oxygen metabolites</subject><subject>RESPONSE MODIFYING FACTORS</subject><subject>RODENTS</subject><subject>Sulfones - therapeutic use</subject><subject>SULFOXIDES</subject><subject>SYMPTOMS</subject><subject>Toxicology</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>VEGETABLES</subject><subject>VERTEBRATES</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM-L1DAUgIMo7uzqP-BBCiKepr6XX23Biyy6KgteVvAW0vSFydBpxiYjzn9vSke9eQoh33vk-xh7gVAjoH67r7O1x5oDYg2iBmwesQ1Cp7cghHjMNgAStwDt9yt2ndIeADop8Sm74ii10FJv2JeHHVXkPblcRV8dKO_OYzqNPk7ncbnZiao4VXnBfh1pDgeash0rF8eQQ6rC-jbb_Iw98XZM9Pxy3rBvHz883H7a3n-9-3z7_n7rpFR52zlp2xbbQSjeKwLXoSStFPbae_S605YT770SqtXYNFYOqkPXd9w3oLQVN-zVujemHExyIZPbuThNxcFwVG3TaCzUm5U6zvHHiVI2h5AcjWMRiqdkOuBCac15IflKujmmNJM3x2Jp57NBMEtoszdLaLOENiBMCV2GXl7Wn_oDDX9H_pQtwOsLYJOzo5_t5EL6x0neKmhk4d6tHJVkPwPNixFNjoYwL0JDDP_7x2_Gj5qd</recordid><startdate>20110615</startdate><enddate>20110615</enddate><creator>Amirshahrokhi, K.</creator><creator>Bohlooli, S.</creator><creator>Chinifroush, M.M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>20110615</creationdate><title>The effect of methylsulfonylmethane on the experimental colitis in the rat</title><author>Amirshahrokhi, K. ; Bohlooli, S. ; Chinifroush, M.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-9c4a8818d352b5e0c914e6551b6ff1f696a2e2bf53586177a4d591cb92f7056a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>ACETIC ACID</topic><topic>ANIMALS</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>ANTIOXIDANTS</topic><topic>Biological and medical sciences</topic><topic>CARBOXYLIC ACIDS</topic><topic>CATALASE</topic><topic>Catalase - metabolism</topic><topic>CHEMICAL REACTIONS</topic><topic>Colitis - drug therapy</topic><topic>Colitis - metabolism</topic><topic>Colitis - pathology</topic><topic>Dimethyl Sulfoxide - therapeutic use</topic><topic>DMSO</topic><topic>DRUGS</topic><topic>ELEMENTS</topic><topic>ENZYMES</topic><topic>Experimental colitis</topic><topic>FOOD</topic><topic>FRUITS</topic><topic>GLUTATHIONE</topic><topic>Glutathione - analysis</topic><topic>INFLAMMATION</topic><topic>Interleukin-1beta - analysis</topic><topic>Male</topic><topic>Malondialdehyde - analysis</topic><topic>MAMMALS</topic><topic>Medical sciences</topic><topic>METABOLITES</topic><topic>Methylsulfonylmethane</topic><topic>MONOCARBOXYLIC ACIDS</topic><topic>NONMETALS</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC SULFUR COMPOUNDS</topic><topic>OXIDATION</topic><topic>OXIDOREDUCTASES</topic><topic>OXYGEN</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PEPTIDES</topic><topic>Peroxidase - metabolism</topic><topic>PEROXIDASES</topic><topic>PLANTS</topic><topic>POLYPEPTIDES</topic><topic>PROTEINS</topic><topic>RADIOPROTECTIVE SUBSTANCES</topic><topic>RATS</topic><topic>Rats, Wistar</topic><topic>Reactive oxygen metabolites</topic><topic>RESPONSE MODIFYING FACTORS</topic><topic>RODENTS</topic><topic>Sulfones - therapeutic use</topic><topic>SULFOXIDES</topic><topic>SYMPTOMS</topic><topic>Toxicology</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>VEGETABLES</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amirshahrokhi, K.</creatorcontrib><creatorcontrib>Bohlooli, S.</creatorcontrib><creatorcontrib>Chinifroush, M.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amirshahrokhi, K.</au><au>Bohlooli, S.</au><au>Chinifroush, M.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of methylsulfonylmethane on the experimental colitis in the rat</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>2011-06-15</date><risdate>2011</risdate><volume>253</volume><issue>3</issue><spage>197</spage><epage>202</epage><pages>197-202</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><coden>TXAPA9</coden><abstract>Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables, has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur compound and a normal oxidative metabolite of dimethyl sulfoxide. This study was carried out to investigate the effect of MSM in a rat model of experimental colitis. Colitis was induced by intracolonic instillation of 1ml of 5% of acetic acid. Rats were treated with MSM (400mg/kg/day, orally) for 4days. Animals were euthanized and distal colon evaluated histologically and biochemically. Tissue samples were used to measurement of malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), glutathione (GSH) and proinflammatory cytokine (TNF-α and IL-1β) levels. Results showed that MSM decreased macroscopic and microscopic colonic damage scores caused by administration of acetic acid. MSM treatment also significantly reduced colonic levels of MDA, MPO and IL-1β, while increased the levels of GSH and CAT compared with acetic acid-induced colitis group. It seems that MSM as a natural product may have a protective effect in an experimental ulcerative colitis.
► Methylsulfonylmethane occurs naturally in some green plants, fruits and vegetables. ► Methylsulfonylmethane (MSM) has anti-inflammatory and antioxidant effects. ► We evaluated the effects of MSM in a rat model of experimental ulcerative colitis. ► MSM has protective effect against acetic acid-induced colitis in rat.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21463646</pmid><doi>10.1016/j.taap.2011.03.017</doi><tpages>6</tpages></addata></record> |
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| ispartof | Toxicology and applied pharmacology, 2011-06, Vol.253 (3), p.197-202 |
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| subjects | 60 APPLIED LIFE SCIENCES ACETIC ACID ANIMALS Anti-Inflammatory Agents - therapeutic use ANTIOXIDANTS Biological and medical sciences CARBOXYLIC ACIDS CATALASE Catalase - metabolism CHEMICAL REACTIONS Colitis - drug therapy Colitis - metabolism Colitis - pathology Dimethyl Sulfoxide - therapeutic use DMSO DRUGS ELEMENTS ENZYMES Experimental colitis FOOD FRUITS GLUTATHIONE Glutathione - analysis INFLAMMATION Interleukin-1beta - analysis Male Malondialdehyde - analysis MAMMALS Medical sciences METABOLITES Methylsulfonylmethane MONOCARBOXYLIC ACIDS NONMETALS ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS OXIDATION OXIDOREDUCTASES OXYGEN PATHOLOGICAL CHANGES PEPTIDES Peroxidase - metabolism PEROXIDASES PLANTS POLYPEPTIDES PROTEINS RADIOPROTECTIVE SUBSTANCES RATS Rats, Wistar Reactive oxygen metabolites RESPONSE MODIFYING FACTORS RODENTS Sulfones - therapeutic use SULFOXIDES SYMPTOMS Toxicology Tumor Necrosis Factor-alpha - analysis VEGETABLES VERTEBRATES |
| title | The effect of methylsulfonylmethane on the experimental colitis in the rat |
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