Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non–Small-Cell Lung Cancer and Radiation Pneumonitis
Purpose To study the relationship between fluorodeoxyglucose (FDG) uptake in pulmonary tissue after radical radiation therapy (RT) and the presence and severity of radiation pneumonitis. Methods and Materials In 88 consecutive patients,18 F-FDG–positron emission tomography was performed at a median...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2011-08, Vol.80 (5), p.1365-1371 |
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| creator | Mac Manus, Michael P., M.D., MRCP., FRCR., FRANZCR Ding, Zhe, M.D Hogg, Annette, B.App.Sc., Ph.D Herschtal, Alan, BE (Hons)., Post Grad. Dip. (App. Stat.) Binns, David, Dip Appl Sci., ANMT Ball, David L., M.D., FRANZCR Hicks, Rodney J., MB BS (Hons)., M.D., FRACP |
| description | Purpose To study the relationship between fluorodeoxyglucose (FDG) uptake in pulmonary tissue after radical radiation therapy (RT) and the presence and severity of radiation pneumonitis. Methods and Materials In 88 consecutive patients,18 F-FDG–positron emission tomography was performed at a median of 70 days after completion of RT. Patients received 60 Gy in 30 fractions, and all but 15 had concurrent platinum-based chemotherapy. RT-induced pulmonary inflammatory changes occurring within the radiation treatment volume were scored, using a visual (0 to 3) radiotoxicity grading scale, by an observer blinded to the presence or absence of clinical radiation pneumonitis. Radiation pneumonitis was retrospectively graded using the Radiation Therapy Oncology Group (RTOG) scale by an observer blinded to the PET radiotoxicity score. Results There was a significant association between the worst RTOG pneumonitis grade occurring at any time after RT and the positron emission tomograph (PET) radiotoxicity grade (one-sided p = 0.033). The worst RTOG pneumonitis grade occurring after the PET scan was also associated with the PET radiotoxicity grade (one-sided p = 0.035). For every one-level increase in the PET toxicity scale, the risk of a higher RTOG radiation pneumonitis score increased by approximately 40%. The PET radiotoxicity score showed no significant correlation with the duration of radiation pneumonitis. Conclusions The intensity of FDG uptake in pulmonary tissue after RT determined using a simple visual scoring system showed significant correlation with the presence and severity of radiation pneumonitis.18 F-FDG–PET may be useful in the prediction, diagnosis and therapeutic monitoring of radiation pneumonitis. |
| doi_str_mv | 10.1016/j.ijrobp.2010.04.021 |
| format | Article |
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Dip. (App. Stat.) ; Binns, David, Dip Appl Sci., ANMT ; Ball, David L., M.D., FRANZCR ; Hicks, Rodney J., MB BS (Hons)., M.D., FRACP</creator><creatorcontrib>Mac Manus, Michael P., M.D., MRCP., FRCR., FRANZCR ; Ding, Zhe, M.D ; Hogg, Annette, B.App.Sc., Ph.D ; Herschtal, Alan, BE (Hons)., Post Grad. Dip. (App. Stat.) ; Binns, David, Dip Appl Sci., ANMT ; Ball, David L., M.D., FRANZCR ; Hicks, Rodney J., MB BS (Hons)., M.D., FRACP</creatorcontrib><description>Purpose To study the relationship between fluorodeoxyglucose (FDG) uptake in pulmonary tissue after radical radiation therapy (RT) and the presence and severity of radiation pneumonitis. Methods and Materials In 88 consecutive patients,18 F-FDG–positron emission tomography was performed at a median of 70 days after completion of RT. Patients received 60 Gy in 30 fractions, and all but 15 had concurrent platinum-based chemotherapy. RT-induced pulmonary inflammatory changes occurring within the radiation treatment volume were scored, using a visual (0 to 3) radiotoxicity grading scale, by an observer blinded to the presence or absence of clinical radiation pneumonitis. Radiation pneumonitis was retrospectively graded using the Radiation Therapy Oncology Group (RTOG) scale by an observer blinded to the PET radiotoxicity score. Results There was a significant association between the worst RTOG pneumonitis grade occurring at any time after RT and the positron emission tomograph (PET) radiotoxicity grade (one-sided p = 0.033). The worst RTOG pneumonitis grade occurring after the PET scan was also associated with the PET radiotoxicity grade (one-sided p = 0.035). For every one-level increase in the PET toxicity scale, the risk of a higher RTOG radiation pneumonitis score increased by approximately 40%. The PET radiotoxicity score showed no significant correlation with the duration of radiation pneumonitis. Conclusions The intensity of FDG uptake in pulmonary tissue after RT determined using a simple visual scoring system showed significant correlation with the presence and severity of radiation pneumonitis.18 F-FDG–PET may be useful in the prediction, diagnosis and therapeutic monitoring of radiation pneumonitis.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2010.04.021</identifier><identifier>PMID: 20675076</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>ANTILEPTONS ; ANTIMATTER ; ANTIMETABOLITES ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; ANTIPARTICLES ; BETA DECAY RADIOISOTOPES ; BETA-PLUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BODY ; Carboplatin - administration & dosage ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - radiotherapy ; CHEMOTHERAPY ; Cisplatin - administration & dosage ; COMPUTERIZED TOMOGRAPHY ; DIAGNOSTIC TECHNIQUES ; DISEASES ; DRUGS ; ELEMENTARY PARTICLES ; ELEMENTS ; EMISSION COMPUTED TOMOGRAPHY ; FERMIONS ; FLUORINE 18 ; FLUORINE ISOTOPES ; FLUORODEOXYGLUCOSE ; Fluorodeoxyglucose F18 - adverse effects ; Fluorodeoxyglucose F18 - pharmacokinetics ; Fluorouracil - administration & dosage ; HAZARDS ; Hematology, Oncology and Palliative Medicine ; HOURS LIVING RADIOISOTOPES ; Humans ; INFLAMMATION ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; LEPTONS ; LIGHT NUCLEI ; Lung - diagnostic imaging ; Lung - metabolism ; Lung - radiation effects ; Lung cancer ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - drug therapy ; Lung Neoplasms - radiotherapy ; LUNGS ; Lymphatic Irradiation ; MATTER ; Medical sciences ; MEDICINE ; METALS ; NANOSECONDS LIVING RADIOISOTOPES ; NEOPLASMS ; NUCLEAR MEDICINE ; NUCLEI ; ODD-ODD NUCLEI ; Oncology ; ORGANS ; Paclitaxel - administration & dosage ; PATHOLOGICAL CHANGES ; PLATINUM ; PLATINUM METALS ; Pneumology ; PNEUMONITIS ; POSITRON COMPUTED TOMOGRAPHY ; Positron emission tomography ; Positron-Emission Tomography - adverse effects ; Positron-Emission Tomography - methods ; POSITRONS ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive - complications ; Radiation ; Radiation pneumonitis ; Radiation Pneumonitis - diagnostic imaging ; Radiation Pneumonitis - metabolism ; Radiation Pneumonitis - pathology ; RADIOISOTOPES ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiopharmaceuticals - adverse effects ; Radiopharmaceuticals - pharmacokinetics ; RADIOTHERAPY ; Radiotherapy Dosage ; RESPIRATORY SYSTEM ; Response assessment ; Risk factors ; Scanning ; SYMPTOMS ; THERAPY ; Time Factors ; TOMOGRAPHY ; Toxicity ; TRANSITION ELEMENTS ; Tumors of the respiratory system and mediastinum</subject><ispartof>International journal of radiation oncology, biology, physics, 2011-08, Vol.80 (5), p.1365-1371</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-e03105ed0fcfea63b18f4ad4a0cf6d2b13e26b32463c9999459357d994d75c43</citedby><cites>FETCH-LOGICAL-c573t-e03105ed0fcfea63b18f4ad4a0cf6d2b13e26b32463c9999459357d994d75c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301610005961$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24391787$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20675076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21587637$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Mac Manus, Michael P., M.D., MRCP., FRCR., FRANZCR</creatorcontrib><creatorcontrib>Ding, Zhe, M.D</creatorcontrib><creatorcontrib>Hogg, Annette, B.App.Sc., Ph.D</creatorcontrib><creatorcontrib>Herschtal, Alan, BE (Hons)., Post Grad. Dip. (App. Stat.)</creatorcontrib><creatorcontrib>Binns, David, Dip Appl Sci., ANMT</creatorcontrib><creatorcontrib>Ball, David L., M.D., FRANZCR</creatorcontrib><creatorcontrib>Hicks, Rodney J., MB BS (Hons)., M.D., FRACP</creatorcontrib><title>Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non–Small-Cell Lung Cancer and Radiation Pneumonitis</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose To study the relationship between fluorodeoxyglucose (FDG) uptake in pulmonary tissue after radical radiation therapy (RT) and the presence and severity of radiation pneumonitis. Methods and Materials In 88 consecutive patients,18 F-FDG–positron emission tomography was performed at a median of 70 days after completion of RT. Patients received 60 Gy in 30 fractions, and all but 15 had concurrent platinum-based chemotherapy. RT-induced pulmonary inflammatory changes occurring within the radiation treatment volume were scored, using a visual (0 to 3) radiotoxicity grading scale, by an observer blinded to the presence or absence of clinical radiation pneumonitis. Radiation pneumonitis was retrospectively graded using the Radiation Therapy Oncology Group (RTOG) scale by an observer blinded to the PET radiotoxicity score. Results There was a significant association between the worst RTOG pneumonitis grade occurring at any time after RT and the positron emission tomograph (PET) radiotoxicity grade (one-sided p = 0.033). The worst RTOG pneumonitis grade occurring after the PET scan was also associated with the PET radiotoxicity grade (one-sided p = 0.035). For every one-level increase in the PET toxicity scale, the risk of a higher RTOG radiation pneumonitis score increased by approximately 40%. The PET radiotoxicity score showed no significant correlation with the duration of radiation pneumonitis. Conclusions The intensity of FDG uptake in pulmonary tissue after RT determined using a simple visual scoring system showed significant correlation with the presence and severity of radiation pneumonitis.18 F-FDG–PET may be useful in the prediction, diagnosis and therapeutic monitoring of radiation pneumonitis.</description><subject>ANTILEPTONS</subject><subject>ANTIMATTER</subject><subject>ANTIMETABOLITES</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>ANTIPARTICLES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-PLUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>Carboplatin - administration & dosage</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - radiotherapy</subject><subject>CHEMOTHERAPY</subject><subject>Cisplatin - administration & dosage</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>DRUGS</subject><subject>ELEMENTARY PARTICLES</subject><subject>ELEMENTS</subject><subject>EMISSION COMPUTED TOMOGRAPHY</subject><subject>FERMIONS</subject><subject>FLUORINE 18</subject><subject>FLUORINE ISOTOPES</subject><subject>FLUORODEOXYGLUCOSE</subject><subject>Fluorodeoxyglucose F18 - adverse effects</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Fluorouracil - administration & dosage</subject><subject>HAZARDS</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>Humans</subject><subject>INFLAMMATION</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>LEPTONS</subject><subject>LIGHT NUCLEI</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - metabolism</subject><subject>Lung - radiation effects</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>LUNGS</subject><subject>Lymphatic Irradiation</subject><subject>MATTER</subject><subject>Medical sciences</subject><subject>MEDICINE</subject><subject>METALS</subject><subject>NANOSECONDS LIVING RADIOISOTOPES</subject><subject>NEOPLASMS</subject><subject>NUCLEAR MEDICINE</subject><subject>NUCLEI</subject><subject>ODD-ODD NUCLEI</subject><subject>Oncology</subject><subject>ORGANS</subject><subject>Paclitaxel - administration & dosage</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PLATINUM</subject><subject>PLATINUM METALS</subject><subject>Pneumology</subject><subject>PNEUMONITIS</subject><subject>POSITRON COMPUTED TOMOGRAPHY</subject><subject>Positron emission tomography</subject><subject>Positron-Emission Tomography - adverse effects</subject><subject>Positron-Emission Tomography - methods</subject><subject>POSITRONS</subject><subject>Prospective Studies</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Radiation</subject><subject>Radiation pneumonitis</subject><subject>Radiation Pneumonitis - diagnostic imaging</subject><subject>Radiation Pneumonitis - metabolism</subject><subject>Radiation Pneumonitis - pathology</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiopharmaceuticals - adverse effects</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy Dosage</subject><subject>RESPIRATORY SYSTEM</subject><subject>Response assessment</subject><subject>Risk factors</subject><subject>Scanning</subject><subject>SYMPTOMS</subject><subject>THERAPY</subject><subject>Time Factors</subject><subject>TOMOGRAPHY</subject><subject>Toxicity</subject><subject>TRANSITION ELEMENTS</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2O0zAUhSMEYoaBN0DIEkJik2LHcdJukEqZAaQKKlokdpZj37TuJHbHToDseAceiHfhSbhRy4_YkE2i6Dv355ybJA8ZnTDKimf7id0HXx0mGcVfNJ_QjN1Kztm0nKVciI-3k3PKC5pyhM-SezHuKaWMlfnd5CyjRSloWZwn3-cxem1VZ70jL6D7DODIqm9a71QYyIdDp66B-JpcNb0P3oD_MmybXvsI5CV0oDswpBrIykfbBaxx2doYx2Ib3_ptUIfdQNZaOWfdlszrDgJ5r8yp4WYHSAyk9oG89e7H12_rVjVNuoCmIcseFQvlNEqUM3_JVg56HNB2Nt5P7tSqifDg9L5INleXm8XrdPnu1ZvFfJlqUfIuBcoZFWBorWtQBa_YtM6VyRXVdWGyinHIiopnecH1DJ9czLgoDX6YUuicXySPj2V97KyM2uLmO-2dQwNkxsS0LHiJ1NMjdQj-pofYSTRD4y7Kge-jZJyJgoosZ4jmR1QHH2OAWh6CbdFyyagc85V7ecxXjvlKmkvMF2WPTh36qgXzW_QrUASenAAVtWrqgP7Z-IfL-YyV03HU50cO0LRPFsK4FKDXxoZxJ-Pt_yb5t4BurLPY8xoGiHvfB4eBSCZjJqlcj7c4niLDKxSzgvGfMm7e1Q</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Mac Manus, Michael P., M.D., MRCP., FRCR., FRANZCR</creator><creator>Ding, Zhe, M.D</creator><creator>Hogg, Annette, B.App.Sc., Ph.D</creator><creator>Herschtal, Alan, BE (Hons)., Post Grad. Dip. (App. Stat.)</creator><creator>Binns, David, Dip Appl Sci., ANMT</creator><creator>Ball, David L., M.D., FRANZCR</creator><creator>Hicks, Rodney J., MB BS (Hons)., M.D., FRACP</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>20110801</creationdate><title>Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non–Small-Cell Lung Cancer and Radiation Pneumonitis</title><author>Mac Manus, Michael P., M.D., MRCP., FRCR., FRANZCR ; Ding, Zhe, M.D ; Hogg, Annette, B.App.Sc., Ph.D ; Herschtal, Alan, BE (Hons)., Post Grad. Dip. 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Dip. (App. Stat.)</creatorcontrib><creatorcontrib>Binns, David, Dip Appl Sci., ANMT</creatorcontrib><creatorcontrib>Ball, David L., M.D., FRANZCR</creatorcontrib><creatorcontrib>Hicks, Rodney J., MB BS (Hons)., M.D., FRACP</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mac Manus, Michael P., M.D., MRCP., FRCR., FRANZCR</au><au>Ding, Zhe, M.D</au><au>Hogg, Annette, B.App.Sc., Ph.D</au><au>Herschtal, Alan, BE (Hons)., Post Grad. Dip. (App. Stat.)</au><au>Binns, David, Dip Appl Sci., ANMT</au><au>Ball, David L., M.D., FRANZCR</au><au>Hicks, Rodney J., MB BS (Hons)., M.D., FRACP</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non–Small-Cell Lung Cancer and Radiation Pneumonitis</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>80</volume><issue>5</issue><spage>1365</spage><epage>1371</epage><pages>1365-1371</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Purpose To study the relationship between fluorodeoxyglucose (FDG) uptake in pulmonary tissue after radical radiation therapy (RT) and the presence and severity of radiation pneumonitis. Methods and Materials In 88 consecutive patients,18 F-FDG–positron emission tomography was performed at a median of 70 days after completion of RT. Patients received 60 Gy in 30 fractions, and all but 15 had concurrent platinum-based chemotherapy. RT-induced pulmonary inflammatory changes occurring within the radiation treatment volume were scored, using a visual (0 to 3) radiotoxicity grading scale, by an observer blinded to the presence or absence of clinical radiation pneumonitis. Radiation pneumonitis was retrospectively graded using the Radiation Therapy Oncology Group (RTOG) scale by an observer blinded to the PET radiotoxicity score. Results There was a significant association between the worst RTOG pneumonitis grade occurring at any time after RT and the positron emission tomograph (PET) radiotoxicity grade (one-sided p = 0.033). The worst RTOG pneumonitis grade occurring after the PET scan was also associated with the PET radiotoxicity grade (one-sided p = 0.035). For every one-level increase in the PET toxicity scale, the risk of a higher RTOG radiation pneumonitis score increased by approximately 40%. The PET radiotoxicity score showed no significant correlation with the duration of radiation pneumonitis. Conclusions The intensity of FDG uptake in pulmonary tissue after RT determined using a simple visual scoring system showed significant correlation with the presence and severity of radiation pneumonitis.18 F-FDG–PET may be useful in the prediction, diagnosis and therapeutic monitoring of radiation pneumonitis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20675076</pmid><doi>10.1016/j.ijrobp.2010.04.021</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 2011-08, Vol.80 (5), p.1365-1371 |
| issn | 0360-3016 1879-355X |
| language | eng |
| recordid | cdi_osti_scitechconnect_21587637 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | ANTILEPTONS ANTIMATTER ANTIMETABOLITES Antineoplastic Combined Chemotherapy Protocols - therapeutic use ANTIPARTICLES BETA DECAY RADIOISOTOPES BETA-PLUS DECAY RADIOISOTOPES Biological and medical sciences BODY Carboplatin - administration & dosage Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - radiotherapy CHEMOTHERAPY Cisplatin - administration & dosage COMPUTERIZED TOMOGRAPHY DIAGNOSTIC TECHNIQUES DISEASES DRUGS ELEMENTARY PARTICLES ELEMENTS EMISSION COMPUTED TOMOGRAPHY FERMIONS FLUORINE 18 FLUORINE ISOTOPES FLUORODEOXYGLUCOSE Fluorodeoxyglucose F18 - adverse effects Fluorodeoxyglucose F18 - pharmacokinetics Fluorouracil - administration & dosage HAZARDS Hematology, Oncology and Palliative Medicine HOURS LIVING RADIOISOTOPES Humans INFLAMMATION ISOMERIC TRANSITION ISOTOPES ISOTOPES LEPTONS LIGHT NUCLEI Lung - diagnostic imaging Lung - metabolism Lung - radiation effects Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - drug therapy Lung Neoplasms - radiotherapy LUNGS Lymphatic Irradiation MATTER Medical sciences MEDICINE METALS NANOSECONDS LIVING RADIOISOTOPES NEOPLASMS NUCLEAR MEDICINE NUCLEI ODD-ODD NUCLEI Oncology ORGANS Paclitaxel - administration & dosage PATHOLOGICAL CHANGES PLATINUM PLATINUM METALS Pneumology PNEUMONITIS POSITRON COMPUTED TOMOGRAPHY Positron emission tomography Positron-Emission Tomography - adverse effects Positron-Emission Tomography - methods POSITRONS Prospective Studies Pulmonary Disease, Chronic Obstructive - complications Radiation Radiation pneumonitis Radiation Pneumonitis - diagnostic imaging Radiation Pneumonitis - metabolism Radiation Pneumonitis - pathology RADIOISOTOPES RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE Radiopharmaceuticals - adverse effects Radiopharmaceuticals - pharmacokinetics RADIOTHERAPY Radiotherapy Dosage RESPIRATORY SYSTEM Response assessment Risk factors Scanning SYMPTOMS THERAPY Time Factors TOMOGRAPHY Toxicity TRANSITION ELEMENTS Tumors of the respiratory system and mediastinum |
| title | Association Between Pulmonary Uptake of Fluorodeoxyglucose Detected by Positron Emission Tomography Scanning After Radiation Therapy for Non–Small-Cell Lung Cancer and Radiation Pneumonitis |
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