Expression of Excision Repair Cross-Complementation Group 1 as Predictive Marker for Nasopharyngeal Cancer Treated With Concurrent Chemoradiotherapy

Purpose Cisplatin-based concurrent chemoradiotherapy is the standard treatment of nasopharyngeal cancer. The expression of excision repair cross-complementation group 1 (ERCC1) has been reported to be associated with resistance to platinum-based chemotherapy. We evaluated whether ERCC1 expression co...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2011-07, Vol.80 (3), p.655-660
Hauptverfasser:	Sun, Jong-Mu, M.D, Ahn, Myung-Ju, M.D., Ph.D, Park, Min Jae, M.D, Lee, Hui-Young, M.D, Ahn, Jin Seok, M.D., Ph.D, Lee, Seungkoo, M.D, Kang, Gu, M.D, Han, Joungho, M.D., Ph.D, Son, Young-Ik, M.D., Ph.D, Baek, Chung-Hwan, M.D., Ph.D, Ahn, Yong Chan, M.D., Ph.D, Park, Keunchil, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Analysis of Variance Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences BIOLOGICAL RECOVERY BIOLOGICAL REPAIR Biomarkers, Tumor - metabolism Carcinoma - drug therapy Carcinoma - metabolism Carcinoma - mortality Carcinoma - pathology Carcinoma - radiotherapy CHEMOTHERAPY cisplatin Cisplatin - therapeutic use Combined Modality Therapy - methods COMBINED THERAPY Combined treatments (chemotherapy of immunotherapy associated with an other treatment) concurrent chemoradiotherapy Confidence Intervals Disease-Free Survival DISEASES DNA REPAIR DNA-Binding Proteins - metabolism Drug Resistance, Neoplasm ELEMENTS Endonucleases - metabolism ERCC1 EXCISION REPAIR Excision repair cross-complementation group 1 Female HAZARDS Hematology, Oncology and Palliative Medicine Humans Male MATHEMATICS Medical sciences MEDICINE METALS Middle Aged MULTIVARIATE ANALYSIS nasopharyngeal cancer Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - mortality Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy NEOPLASMS Otorhinolaryngology. Stomatology Pharmacology. Drug treatments PLATINUM PLATINUM METALS predictive factor Radiology RADIOLOGY AND NUCLEAR MEDICINE REPAIR STATISTICS THERAPY TRANSITION ELEMENTS Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Young Adult
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