In Vivo Near-Infrared Spectroscopy and Magnetic Resonance Imaging Monitoring of Tumor Response to Combretastatin A-4-Phosphate Correlated With Therapeutic Outcome

Purpose To develop a combination treatment consisting of combretastatin A-4-phosphate (CA4P) with radiation based on tumor oxygenation status. Methods and Materials In vivo near-infrared spectroscopy (NIRS) and diffusion-weighted (DW) magnetic resonance imaging (MRI) were applied to noninvasively mo...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2011-06, Vol.80 (2), p.574-581
Hauptverfasser:	Zhao, Dawen, M.D., Ph.D, Chang, Cheng-Hui, Ph.D, Kim, Jae G., Ph.D, Liu, Hanli, Ph.D, Mason, Ralph P., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	ABSORPTION SPECTROSCOPY ANIMALS Antineoplastic Agents, Phytogenic - therapeutic use ANTINEOPLASTIC DRUGS Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BODY BODY FLUIDS CARBOXYLIC ACIDS CARCINOMAS Cell Hypoxia Combined Modality Therapy - methods COMBINED THERAPY Combined treatment Combretastatin A-4-phosphate DIAGNOSTIC TECHNIQUES DIFFUSION Diffusion Magnetic Resonance Imaging - methods Diffusion-weighted MRI DISEASES DRUGS ELECTROMAGNETIC RADIATION ELEMENTS Female FUNCTIONS GLANDS GLOBINS Gynecology. Andrology. Obstetrics Hematology, Oncology and Palliative Medicine HEMOGLOBIN Hemoglobins - analysis HETEROCYCLIC ACIDS HETEROCYCLIC COMPOUNDS Hypoxia IN VIVO INFRARED RADIATION INFRARED SPECTRA MAMMALS Mammary gland diseases MAMMARY GLANDS Mammary Neoplasms, Experimental - blood Mammary Neoplasms, Experimental - blood supply Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - radiotherapy MATERIALS Medical sciences MEDICINE NEAR INFRARED RADIATION Near-infrared spectroscopy NECROSIS Necrosis - blood NEOPLASMS NMR IMAGING NONMETALS NUCLEAR MEDICINE ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS OXYGEN Oxygen - administration & dosage Oxygen - blood Oxyhemoglobins - analysis PATHOLOGICAL CHANGES PIGMENTS PORPHYRINS PROTEINS Radiation RADIATIONS RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY RATS Rats, Inbred F344 RESPONSE FUNCTIONS RODENTS SPECTRA SPECTROSCOPY Spectroscopy, Near-Infrared Stilbenes - therapeutic use THERAPY Time Factors Treatment. General aspects Tumors VERTEBRATES
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