Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

Endothelial apoptosis is a driving force in atherosclerosis development. Oxidized low-density lipoprotein (oxLDL) promotes inflammatory and thrombotic processes and is highly atherogenic, as it stimulates macrophage cholesterol accumulation and foam cell formation. Previous studies have shown that t...

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Veröffentlicht in:	Toxicology and applied pharmacology 2010-10, Vol.248 (2), p.134-143
Hauptverfasser:	Ou, Hsiu-Chung, Lee, Wen-Jane, Lee, Shin-Da, Huang, Chih-Yang, Chiu, Tsan-Hung, Tsai, Kun-Ling, Hsu, Wen-Cheng, Sheu, Wayne Huey-Herng
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 60 APPLIED LIFE SCIENCES Akt ANIMAL TISSUES ANTIOXIDANTS APOPTOSIS Apoptosis - drug effects AROMATICS ARTERIOSCLEROSIS Biological and medical sciences BODY Calcium - metabolism CARDIOVASCULAR DISEASES Caspase 3 - metabolism Cells, Cultured Chemical mutagenesis DISEASES Ellagic acid Ellagic Acid - pharmacology Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelial Cells - metabolism ENDOTHELIUM Enzyme Activation - drug effects Humans HYDROXY COMPOUNDS INHIBITION LIPIDS LIPOPROTEINS Lipoproteins, LDL - metabolism Lipoproteins, LDL - toxicity Medical sciences Membrane Potential, Mitochondrial - drug effects NF-kappa B - metabolism Nitric Oxide Synthase Type III - metabolism ORGANIC COMPOUNDS Oxidation-Reduction - drug effects OXIDIZERS oxLDL PHENOLS Phosphatidylinositol 3-Kinases - metabolism Protective Agents - pharmacology PROTEINS Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism ROS Signal Transduction - drug effects Toxicology VASCULAR DISEASES
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