Ventilatory function assessment in safety pharmacology: Optimization of rodent studies using normocapnic or hypercapnic conditions

Although the whole body plethysmography for unrestrained animals is the most widely used method to assess the respiratory risk of new drugs in safety pharmacology, non-appropriate experimental conditions may mask deleterious side effects of some substances. If stimulant or bronchodilatory effects ca...

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Veröffentlicht in:	Toxicology and applied pharmacology 2010-09, Vol.247 (3), p.191-197
Hauptverfasser:	Goineau, Sonia, Rompion, Sonia, Guillaume, Philippe, Picard, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AIR Airway function ALKALOIDS ANALGESICS ANIMALS AROMATICS AZAARENES Biological and medical sciences Bronchodilation CARDIOVASCULAR AGENTS CENTRAL NERVOUS SYSTEM AGENTS CENTRAL NERVOUS SYSTEM DEPRESSANTS DIURETICS DRUGS FLUIDS GASES GUINEA PIGS HAZARDS HEALTH HAZARDS HETEROCYCLIC COMPOUNDS Hypercapnia Hypercapnia - physiopathology Male MAMMALS Medical sciences MICE Mice, Inbred BALB C Models, Animal MORPHINE Morphine - pharmacology NARCOTICS OPIUM OPTIMIZATION ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS PHARMACOLOGY Pharmacology - methods Pharmacology - standards Plethysmography, Whole Body - methods Plethysmography, Whole Body - standards Pneumology PURINES RATS Rats, Wistar RESPIRATION Respiratory depression Respiratory Physiological Phenomena - drug effects Respiratory system : syndromes and miscellaneous diseases RODENTS SAFETY Safety pharmacology Species Specificity THEOPHYLLINE Theophylline - pharmacology Toxicology VASODILATORS VERTEBRATES Whole body plethysmography XANTHINES
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