Classification of sensitizing and irritative potential in a combined in-vitro assay

We have developed a coculture system which in parallel indicates the sensitizing and irritative potential of xenobiotics. The assay is named loose-fit coculture-based sensitization assay (LCSA) and may be performed within 5 days. The system is composed of human monocytes that differentiate to a kind...

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Veröffentlicht in:	Toxicology and applied pharmacology 2010-06, Vol.245 (2), p.211-218
Hauptverfasser:	Wanner, Reinhard, Sonnenburg, Anna, Quatchadze, Maria, Schreiner, Maximilian, Peiser, Matthias, Zuberbier, Torsten, Stahlmann, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Allergens Allergens - immunology Allergens - toxicity Animals B7-2 Antigen - metabolism Biological and medical sciences Biological Assay BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS Cell Differentiation Coculture Techniques Contact allergens Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Dermatitis, Allergic Contact - immunology Dermatology contact dermatitis Humans Immunologic tests IN VITRO In-vitro tests Irritants - immunology Irritants - toxicity Keratinocytes - cytology Keratinocytes - drug effects LEUKOCYTES MATERIALS Medical sciences Mice MONOCYTES Monocytes - cytology Monocytes - drug effects Monocytes - immunology POTENTIALS REAGENTS Respiratory Hypersensitivity - immunology SENSITIZERS Toxicology XENOBIOTICS Xenobiotics - immunology Xenobiotics - toxicity
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