Irradiation-Dependent Effects on Tumor Perfusion and Endogenous and Exogenous Hypoxia Markers in an A549 Xenograft Model

Purpose Hypoxia is a major determinant of tumor radiosensitivity, and microenvironmental changes in response to ionizing radiation (IR) are often heterogenous. We analyzed IR-dependent changes in hypoxia and perfusion in A549 human lung adenocarcinoma xenografts. Materials and Methods Immunohistolog...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2010-08, Vol.77 (5), p.1500-1508
Hauptverfasser:	Fokas, Emmanouil, M.D, Hänze, Jörg, Ph.D, Kamlah, Florentine, D.V.M, Eul, Bastian G., M.D, Lang, Nico, M.D, Keil, Boris, M.D, Heverhagen, Johannes T., M.D., Ph.D, Engenhart-Cabillic, Rita, M.D, An, Hanxiang, M.D, Rose, Frank, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 xenograft Adenocarcinoma - blood supply Adenocarcinoma - metabolism Adenocarcinoma - radiotherapy Animals ANOXIA Apoptosis - radiation effects Benzimidazoles - metabolism Biological and medical sciences BIOLOGICAL MARKERS Biomarkers - metabolism BODY CARCINOMAS Caspase 3 - analysis Caspase 3 - immunology Cell Hypoxia - radiation effects Contrast Media - metabolism DCE-MRI DIAGNOSTIC TECHNIQUES DISEASES Gadolinium - metabolism Glucose Transporter Type 1 - metabolism Hematology, Oncology and Palliative Medicine Humans hypoxia Irradiation Lung Neoplasms - blood supply Lung Neoplasms - metabolism Lung Neoplasms - radiotherapy LUNGS Magnetic Resonance Imaging - methods Male Medical sciences Mice Mice, Nude Microscopy, Fluorescence NEOPLASMS Nitroimidazoles - metabolism NMR IMAGING ORGANS perfusion Platelet Endothelial Cell Adhesion Molecule-1 - analysis Platelet Endothelial Cell Adhesion Molecule-1 - immunology Pneumology Radiation therapy and radiosensitizing agent Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOSENSITIVITY RESPIRATORY SYSTEM SENSITIVITY Time Factors Transplantation, Heterologous Treatment with physical agents Treatment. General aspects Tumors Tumors of the respiratory system and mediastinum
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