Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat
Abstract This report describes the discovery and characterization of a new fusogenic orthoreovirus, Broome virus (BroV), isolated from a little red flying-fox ( Pteropus scapulatus ). The BroV genome consists of 10 dsRNA segments, each having a 3′ terminal pentanucleotide sequence conserved amongst...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2010-06, Vol.402 (1), p.26-40 |
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| container_title | Virology (New York, N.Y.) |
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| creator | Thalmann, Claudia M Cummins, David Michael Yu, Meng Lunt, Ross Pritchard, Lindsay Ian Hansson, Eric Crameri, Sandra Hyatt, Alex Wang, Lin-Fa |
| description | Abstract This report describes the discovery and characterization of a new fusogenic orthoreovirus, Broome virus (BroV), isolated from a little red flying-fox ( Pteropus scapulatus ). The BroV genome consists of 10 dsRNA segments, each having a 3′ terminal pentanucleotide sequence conserved amongst all members of the genus Orthoreovirus , and a unique 5′ terminal pentanucleotide sequence. The smallest genome segment is bicistronic and encodes two small nonstructural proteins, one of which is a novel fusion associated small transmembrane (FAST) protein responsible for syncytium formation, but no cell attachment protein. The low amino acid sequence identity between BroV proteins and those of other orthoreoviruses (13–50%), combined with phylogenetic analyses of structural and nonstructural proteins provide evidence to support the classification of BroV in a new sixth species group within the genus Orthoreovirus. |
| doi_str_mv | 10.1016/j.virol.2009.11.048 |
| format | Article |
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The BroV genome consists of 10 dsRNA segments, each having a 3′ terminal pentanucleotide sequence conserved amongst all members of the genus Orthoreovirus , and a unique 5′ terminal pentanucleotide sequence. The smallest genome segment is bicistronic and encodes two small nonstructural proteins, one of which is a novel fusion associated small transmembrane (FAST) protein responsible for syncytium formation, but no cell attachment protein. The low amino acid sequence identity between BroV proteins and those of other orthoreoviruses (13–50%), combined with phylogenetic analyses of structural and nonstructural proteins provide evidence to support the classification of BroV in a new sixth species group within the genus Orthoreovirus.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2009.11.048</identifier><identifier>PMID: 20350736</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; AMINO ACID SEQUENCE ; ANIMALS ; Australia ; Bat ; BATS ; Broome virus ; Cell Line ; Chiroptera - virology ; Cluster Analysis ; Cricetinae ; FAST protein, Small nonstructural proteins ; Flying-fox ; FOOD ; FRUITS ; Fusogenic orthoreovirus ; Genome, Viral ; Infectious Disease ; MAMMALS ; MICROORGANISMS ; Molecular Sequence Data ; MOLECULAR STRUCTURE ; ORGANIC COMPOUNDS ; Orthoreovirus ; Orthoreovirus - classification ; Orthoreovirus - genetics ; Orthoreovirus - isolation & purification ; PARASITES ; Phylogeny ; PROTEINS ; Pteropus scapulatus ; Reoviridae Infections - veterinary ; RNA, Double-Stranded - genetics ; RNA, Viral - genetics ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; VERTEBRATES ; Viral Proteins - genetics ; VIRUSES</subject><ispartof>Virology (New York, N.Y.), 2010-06, Vol.402 (1), p.26-40</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>Copyright (c) 2010 Elsevier Inc. 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The BroV genome consists of 10 dsRNA segments, each having a 3′ terminal pentanucleotide sequence conserved amongst all members of the genus Orthoreovirus , and a unique 5′ terminal pentanucleotide sequence. The smallest genome segment is bicistronic and encodes two small nonstructural proteins, one of which is a novel fusion associated small transmembrane (FAST) protein responsible for syncytium formation, but no cell attachment protein. The low amino acid sequence identity between BroV proteins and those of other orthoreoviruses (13–50%), combined with phylogenetic analyses of structural and nonstructural proteins provide evidence to support the classification of BroV in a new sixth species group within the genus Orthoreovirus.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>AMINO ACID SEQUENCE</subject><subject>ANIMALS</subject><subject>Australia</subject><subject>Bat</subject><subject>BATS</subject><subject>Broome virus</subject><subject>Cell Line</subject><subject>Chiroptera - virology</subject><subject>Cluster Analysis</subject><subject>Cricetinae</subject><subject>FAST protein, Small nonstructural proteins</subject><subject>Flying-fox</subject><subject>FOOD</subject><subject>FRUITS</subject><subject>Fusogenic orthoreovirus</subject><subject>Genome, Viral</subject><subject>Infectious Disease</subject><subject>MAMMALS</subject><subject>MICROORGANISMS</subject><subject>Molecular Sequence Data</subject><subject>MOLECULAR STRUCTURE</subject><subject>ORGANIC COMPOUNDS</subject><subject>Orthoreovirus</subject><subject>Orthoreovirus - classification</subject><subject>Orthoreovirus - genetics</subject><subject>Orthoreovirus - isolation & purification</subject><subject>PARASITES</subject><subject>Phylogeny</subject><subject>PROTEINS</subject><subject>Pteropus scapulatus</subject><subject>Reoviridae Infections - veterinary</subject><subject>RNA, Double-Stranded - genetics</subject><subject>RNA, Viral - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>VERTEBRATES</subject><subject>Viral Proteins - genetics</subject><subject>VIRUSES</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1vFSEUhonR2NvqLzAxJC7cdMYDzMDMQpPa-JU06UJduCJc5mC5zgy3wNT038v0VhduugLC8x5yeA4hLxjUDJh8s6tvfAxjzQH6mrEamu4R2TDoZQWiYY_JBqDhlew4PyLHKe2gnJWCp-SIg2hBCbkhP97HECakpdSSTqmhM_6mbknhJ87e0suYr0LEcHdN0x6tx0R9CqPJOFAXw0TNTM-WlKMZfdm6uPhMtyY_I0-cGRM-v19PyPePH76df64uLj99OT-7qGwr-lw1bosCbG854CC4s1whMz1aLl03yAH7fpCNMNwpVlpBKQGlZR0qo1qGKE7Iq0PdkLLXyfqM9sqGeUabNWcNk0y1hXp9oPYxXC-Ysp58sjiOZsawJN21olGdkt2DpBKi5arhvJDiQNoYUoro9D76ycRbzUCvivRO3ynSqyLNmC6KSurlff1lO-HwL_PXSQHeHgAsv3bjMa5N4Wxx8HHtaQj-gQfe_Ze3oy8yzfgLbzHtwhLnIkQznbgG_XWdknVIoAdQXSPEHwUXuEA</recordid><startdate>20100620</startdate><enddate>20100620</enddate><creator>Thalmann, Claudia M</creator><creator>Cummins, David Michael</creator><creator>Yu, Meng</creator><creator>Lunt, Ross</creator><creator>Pritchard, Lindsay Ian</creator><creator>Hansson, Eric</creator><creator>Crameri, Sandra</creator><creator>Hyatt, Alex</creator><creator>Wang, Lin-Fa</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>OTOTI</scope></search><sort><creationdate>20100620</creationdate><title>Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat</title><author>Thalmann, Claudia M ; Cummins, David Michael ; Yu, Meng ; Lunt, Ross ; Pritchard, Lindsay Ian ; Hansson, Eric ; Crameri, Sandra ; Hyatt, Alex ; Wang, Lin-Fa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-4fbe30c9c20ed32fc27e1a9ec26f8d6de99d643a2f71682e660e6c18e7a751ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>AMINO ACID SEQUENCE</topic><topic>ANIMALS</topic><topic>Australia</topic><topic>Bat</topic><topic>BATS</topic><topic>Broome virus</topic><topic>Cell Line</topic><topic>Chiroptera - virology</topic><topic>Cluster Analysis</topic><topic>Cricetinae</topic><topic>FAST protein, Small nonstructural proteins</topic><topic>Flying-fox</topic><topic>FOOD</topic><topic>FRUITS</topic><topic>Fusogenic orthoreovirus</topic><topic>Genome, Viral</topic><topic>Infectious Disease</topic><topic>MAMMALS</topic><topic>MICROORGANISMS</topic><topic>Molecular Sequence Data</topic><topic>MOLECULAR STRUCTURE</topic><topic>ORGANIC COMPOUNDS</topic><topic>Orthoreovirus</topic><topic>Orthoreovirus - classification</topic><topic>Orthoreovirus - genetics</topic><topic>Orthoreovirus - isolation & purification</topic><topic>PARASITES</topic><topic>Phylogeny</topic><topic>PROTEINS</topic><topic>Pteropus scapulatus</topic><topic>Reoviridae Infections - veterinary</topic><topic>RNA, Double-Stranded - genetics</topic><topic>RNA, Viral - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>VERTEBRATES</topic><topic>Viral Proteins - genetics</topic><topic>VIRUSES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thalmann, Claudia M</creatorcontrib><creatorcontrib>Cummins, David Michael</creatorcontrib><creatorcontrib>Yu, Meng</creatorcontrib><creatorcontrib>Lunt, Ross</creatorcontrib><creatorcontrib>Pritchard, Lindsay Ian</creatorcontrib><creatorcontrib>Hansson, Eric</creatorcontrib><creatorcontrib>Crameri, Sandra</creatorcontrib><creatorcontrib>Hyatt, Alex</creatorcontrib><creatorcontrib>Wang, Lin-Fa</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thalmann, Claudia M</au><au>Cummins, David Michael</au><au>Yu, Meng</au><au>Lunt, Ross</au><au>Pritchard, Lindsay Ian</au><au>Hansson, Eric</au><au>Crameri, Sandra</au><au>Hyatt, Alex</au><au>Wang, Lin-Fa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>2010-06-20</date><risdate>2010</risdate><volume>402</volume><issue>1</issue><spage>26</spage><epage>40</epage><pages>26-40</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>Abstract This report describes the discovery and characterization of a new fusogenic orthoreovirus, Broome virus (BroV), isolated from a little red flying-fox ( Pteropus scapulatus ). The BroV genome consists of 10 dsRNA segments, each having a 3′ terminal pentanucleotide sequence conserved amongst all members of the genus Orthoreovirus , and a unique 5′ terminal pentanucleotide sequence. The smallest genome segment is bicistronic and encodes two small nonstructural proteins, one of which is a novel fusion associated small transmembrane (FAST) protein responsible for syncytium formation, but no cell attachment protein. The low amino acid sequence identity between BroV proteins and those of other orthoreoviruses (13–50%), combined with phylogenetic analyses of structural and nonstructural proteins provide evidence to support the classification of BroV in a new sixth species group within the genus Orthoreovirus.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20350736</pmid><doi>10.1016/j.virol.2009.11.048</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Virology (New York, N.Y.), 2010-06, Vol.402 (1), p.26-40 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | 60 APPLIED LIFE SCIENCES AMINO ACID SEQUENCE ANIMALS Australia Bat BATS Broome virus Cell Line Chiroptera - virology Cluster Analysis Cricetinae FAST protein, Small nonstructural proteins Flying-fox FOOD FRUITS Fusogenic orthoreovirus Genome, Viral Infectious Disease MAMMALS MICROORGANISMS Molecular Sequence Data MOLECULAR STRUCTURE ORGANIC COMPOUNDS Orthoreovirus Orthoreovirus - classification Orthoreovirus - genetics Orthoreovirus - isolation & purification PARASITES Phylogeny PROTEINS Pteropus scapulatus Reoviridae Infections - veterinary RNA, Double-Stranded - genetics RNA, Viral - genetics Sequence Analysis, DNA Sequence Homology, Amino Acid VERTEBRATES Viral Proteins - genetics VIRUSES |
| title | Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat |
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