Comparison of Positron Emission Tomography Scanning and Sentinel Node Biopsy in the Detection of Inguinal Node Metastases in Patients With Anal Cancer
Background Inguinal lymph node metastases in patients with anal cancer are an independent prognostic factor for local failure and overall mortality. Inguinal lymph node status can be adequately assessed with sentinel node biopsy, and the radiotherapy strategy can subsequently be changed. We compared...
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| creator | Mistrangelo, Massimiliano, Ph.D., M.D Pelosi, Ettore, M.D Bellò, Marilena, M.D Castellano, Isabella, M.D Cassoni, Paola, Ph.D., M.D Ricardi, Umberto, M.D Munoz, Fernando, M.D Racca, Patrizia, M.D Contu, Viviana, M.D Beltramo, Giancarlo, M.D Morino, Mario, M.D Mussa, Antonio, M.D |
| description | Background Inguinal lymph node metastases in patients with anal cancer are an independent prognostic factor for local failure and overall mortality. Inguinal lymph node status can be adequately assessed with sentinel node biopsy, and the radiotherapy strategy can subsequently be changed. We compared this technique vs. dedicated 18F-fluorodeoxyglucose positron emission tomography (PET) to determine which was the better tool for staging inguinal lymph nodes. Methods and Materials In our department, 27 patients (9 men and 18 women) underwent both inguinal sentinel node biopsy and PET-CT. PET-CT was performed before treatment and then at 1 and 3 months after treatment. Results PET-CT scans detected no inguinal metastases in 20 of 27 patients and metastases in the remaining 7. Histologic analysis of the sentinel lymph node detected metastases in only three patients (four PET-CT false positives). HIV status was not found to influence the results. None of the patients negative at sentinel node biopsy developed metastases during the follow-up period. PET-CT had a sensitivity of 100%, with a negative predictive value of 100%. Owing to the high number of false positives, PET-CT specificity was 83%, and positive predictive value was 43%. Conclusions In this series of patients with anal cancer, inguinal sentinel node biopsy was superior to PET-CT for staging inguinal lymph nodes. |
| doi_str_mv | 10.1016/j.ijrobp.2009.04.020 |
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Inguinal lymph node status can be adequately assessed with sentinel node biopsy, and the radiotherapy strategy can subsequently be changed. We compared this technique vs. dedicated 18F-fluorodeoxyglucose positron emission tomography (PET) to determine which was the better tool for staging inguinal lymph nodes. Methods and Materials In our department, 27 patients (9 men and 18 women) underwent both inguinal sentinel node biopsy and PET-CT. PET-CT was performed before treatment and then at 1 and 3 months after treatment. Results PET-CT scans detected no inguinal metastases in 20 of 27 patients and metastases in the remaining 7. Histologic analysis of the sentinel lymph node detected metastases in only three patients (four PET-CT false positives). HIV status was not found to influence the results. None of the patients negative at sentinel node biopsy developed metastases during the follow-up period. PET-CT had a sensitivity of 100%, with a negative predictive value of 100%. Owing to the high number of false positives, PET-CT specificity was 83%, and positive predictive value was 43%. Conclusions In this series of patients with anal cancer, inguinal sentinel node biopsy was superior to PET-CT for staging inguinal lymph nodes.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2009.04.020</identifier><identifier>PMID: 19632066</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Anal cancer ; ANTIMETABOLITES ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Anus Neoplasms - diagnostic imaging ; Anus Neoplasms - drug therapy ; Anus Neoplasms - pathology ; Anus Neoplasms - radiotherapy ; BETA DECAY RADIOISOTOPES ; BETA-PLUS DECAY RADIOISOTOPES ; BIOPSY ; BODY ; Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Combined Modality Therapy - methods ; COMPUTERIZED TOMOGRAPHY ; DIAGNOSTIC TECHNIQUES ; DIGESTIVE SYSTEM ; DISEASES ; DRUGS ; EMISSION COMPUTED TOMOGRAPHY ; False Positive Reactions ; Female ; FLUORINE 18 ; FLUORINE ISOTOPES ; FLUORODEOXYGLUCOSE ; Fluorodeoxyglucose F18 ; GASTROINTESTINAL TRACT ; Hematology, Oncology and Palliative Medicine ; HOURS LIVING RADIOISOTOPES ; Human immunodeficiency virus ; Humans ; Inguinal Canal ; INTESTINES ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; LIGHT NUCLEI ; Lymph node metastases ; LYMPH NODES ; Lymph Nodes - diagnostic imaging ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis - diagnosis ; Lymphatic Metastasis - pathology ; LYMPHATIC SYSTEM ; Male ; MEDICINE ; METASTASES ; Middle Aged ; NANOSECONDS LIVING RADIOISOTOPES ; Neoplasm Staging - methods ; NEOPLASMS ; NUCLEAR MEDICINE ; NUCLEI ; ODD-ODD NUCLEI ; ORGANS ; PET-CT ; POSITRON COMPUTED TOMOGRAPHY ; Positron-Emission Tomography - methods ; RADIOISOTOPES ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiopharmaceuticals ; RADIOTHERAPY ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy - methods ; Sentinel lymph node metastases ; Squamous cancer ; THERAPY ; TOMOGRAPHY</subject><ispartof>International journal of radiation oncology, biology, physics, 2010-05, Vol.77 (1), p.73-78</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-f6c7cd5989fe05ff86671e9e052ea02cd1e51096dad8103928bea435008b85bd3</citedby><cites>FETCH-LOGICAL-c476t-f6c7cd5989fe05ff86671e9e052ea02cd1e51096dad8103928bea435008b85bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2009.04.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19632066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21372242$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Mistrangelo, Massimiliano, Ph.D., M.D</creatorcontrib><creatorcontrib>Pelosi, Ettore, M.D</creatorcontrib><creatorcontrib>Bellò, Marilena, M.D</creatorcontrib><creatorcontrib>Castellano, Isabella, M.D</creatorcontrib><creatorcontrib>Cassoni, Paola, Ph.D., M.D</creatorcontrib><creatorcontrib>Ricardi, Umberto, M.D</creatorcontrib><creatorcontrib>Munoz, Fernando, M.D</creatorcontrib><creatorcontrib>Racca, Patrizia, M.D</creatorcontrib><creatorcontrib>Contu, Viviana, M.D</creatorcontrib><creatorcontrib>Beltramo, Giancarlo, M.D</creatorcontrib><creatorcontrib>Morino, Mario, M.D</creatorcontrib><creatorcontrib>Mussa, Antonio, M.D</creatorcontrib><title>Comparison of Positron Emission Tomography Scanning and Sentinel Node Biopsy in the Detection of Inguinal Node Metastases in Patients With Anal Cancer</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Background Inguinal lymph node metastases in patients with anal cancer are an independent prognostic factor for local failure and overall mortality. Inguinal lymph node status can be adequately assessed with sentinel node biopsy, and the radiotherapy strategy can subsequently be changed. We compared this technique vs. dedicated 18F-fluorodeoxyglucose positron emission tomography (PET) to determine which was the better tool for staging inguinal lymph nodes. Methods and Materials In our department, 27 patients (9 men and 18 women) underwent both inguinal sentinel node biopsy and PET-CT. PET-CT was performed before treatment and then at 1 and 3 months after treatment. Results PET-CT scans detected no inguinal metastases in 20 of 27 patients and metastases in the remaining 7. Histologic analysis of the sentinel lymph node detected metastases in only three patients (four PET-CT false positives). HIV status was not found to influence the results. None of the patients negative at sentinel node biopsy developed metastases during the follow-up period. PET-CT had a sensitivity of 100%, with a negative predictive value of 100%. Owing to the high number of false positives, PET-CT specificity was 83%, and positive predictive value was 43%. Conclusions In this series of patients with anal cancer, inguinal sentinel node biopsy was superior to PET-CT for staging inguinal lymph nodes.</description><subject>Adult</subject><subject>Aged</subject><subject>Anal cancer</subject><subject>ANTIMETABOLITES</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Anus Neoplasms - diagnostic imaging</subject><subject>Anus Neoplasms - drug therapy</subject><subject>Anus Neoplasms - pathology</subject><subject>Anus Neoplasms - radiotherapy</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-PLUS DECAY RADIOISOTOPES</subject><subject>BIOPSY</subject><subject>BODY</subject><subject>Carcinoma, Squamous Cell - diagnostic imaging</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Combined Modality Therapy - methods</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DIGESTIVE SYSTEM</subject><subject>DISEASES</subject><subject>DRUGS</subject><subject>EMISSION COMPUTED TOMOGRAPHY</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>FLUORINE 18</subject><subject>FLUORINE ISOTOPES</subject><subject>FLUORODEOXYGLUCOSE</subject><subject>Fluorodeoxyglucose F18</subject><subject>GASTROINTESTINAL TRACT</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Inguinal Canal</subject><subject>INTESTINES</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>LIGHT NUCLEI</subject><subject>Lymph node metastases</subject><subject>LYMPH NODES</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Lymphatic Metastasis - pathology</subject><subject>LYMPHATIC SYSTEM</subject><subject>Male</subject><subject>MEDICINE</subject><subject>METASTASES</subject><subject>Middle Aged</subject><subject>NANOSECONDS LIVING RADIOISOTOPES</subject><subject>Neoplasm Staging - methods</subject><subject>NEOPLASMS</subject><subject>NUCLEAR MEDICINE</subject><subject>NUCLEI</subject><subject>ODD-ODD NUCLEI</subject><subject>ORGANS</subject><subject>PET-CT</subject><subject>POSITRON COMPUTED TOMOGRAPHY</subject><subject>Positron-Emission Tomography - methods</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiopharmaceuticals</subject><subject>RADIOTHERAPY</subject><subject>Sensitivity and Specificity</subject><subject>Sentinel Lymph Node Biopsy - methods</subject><subject>Sentinel lymph node metastases</subject><subject>Squamous cancer</subject><subject>THERAPY</subject><subject>TOMOGRAPHY</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt-KEzEUxgdR3Lr6BiIBL7xqPUlmMsmNsFt3dWHVha7oXUgzZ9rUaTIm04W-iM9rhikI3iwEci5-5zt_vlMUryksKFDxfrdwuxjW_YIBqAWUC2DwpJhRWas5r6qfT4sZcAFznuGz4kVKOwCgtC6fF2dUCc5AiFnxZxn2vYkuBU9CS-5CckPM8dXepeRycB_2YRNNvz2SlTXeO78hxjdkhX5wHjvyNTRILl3o05E4T4Ytko84oB3cJHnjNwfnzQn8goNJ-WEa4TszuKyTyA83bMnFSC2NtxhfFs9a0yV8dfrPi-_XV_fLz_Pbb59ulhe3c1vWYpi3wta2qZRULULVtlKImqLKMUMDzDYUKwpKNKaRFLhico2m5BWAXMtq3fDz4u2kG9LgdLIuN761wfvcv2aU14yVLFPvJqqP4fcB06Dzdix2nfEYDknXpYBacqkeJ3mmaKmqTJYTaWNIKWKr--j2Jh41BT0arHd6MliPBmsodTY4p705FTis99j8Szo5moEPE4B5bQ8O4zgV5p02Lo5DNcE9VuF_Ads576zpfuER0y4cYvYpaaoT06BX45GNNwYKoJKy5H8B3dXOiw</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Mistrangelo, Massimiliano, Ph.D., M.D</creator><creator>Pelosi, Ettore, M.D</creator><creator>Bellò, Marilena, M.D</creator><creator>Castellano, Isabella, M.D</creator><creator>Cassoni, Paola, Ph.D., M.D</creator><creator>Ricardi, Umberto, M.D</creator><creator>Munoz, Fernando, M.D</creator><creator>Racca, Patrizia, M.D</creator><creator>Contu, Viviana, M.D</creator><creator>Beltramo, Giancarlo, M.D</creator><creator>Morino, Mario, M.D</creator><creator>Mussa, Antonio, M.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>OTOTI</scope></search><sort><creationdate>20100501</creationdate><title>Comparison of Positron Emission Tomography Scanning and Sentinel Node Biopsy in the Detection of Inguinal Node Metastases in Patients With Anal Cancer</title><author>Mistrangelo, Massimiliano, Ph.D., M.D ; Pelosi, Ettore, M.D ; Bellò, Marilena, M.D ; Castellano, Isabella, M.D ; Cassoni, Paola, Ph.D., M.D ; Ricardi, Umberto, M.D ; Munoz, Fernando, M.D ; Racca, Patrizia, M.D ; Contu, Viviana, M.D ; Beltramo, Giancarlo, M.D ; Morino, Mario, M.D ; Mussa, Antonio, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-f6c7cd5989fe05ff86671e9e052ea02cd1e51096dad8103928bea435008b85bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anal cancer</topic><topic>ANTIMETABOLITES</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Anus Neoplasms - diagnostic imaging</topic><topic>Anus Neoplasms - drug therapy</topic><topic>Anus Neoplasms - pathology</topic><topic>Anus Neoplasms - radiotherapy</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-PLUS DECAY RADIOISOTOPES</topic><topic>BIOPSY</topic><topic>BODY</topic><topic>Carcinoma, Squamous Cell - diagnostic imaging</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Combined Modality Therapy - methods</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DIGESTIVE SYSTEM</topic><topic>DISEASES</topic><topic>DRUGS</topic><topic>EMISSION COMPUTED TOMOGRAPHY</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>FLUORINE 18</topic><topic>FLUORINE ISOTOPES</topic><topic>FLUORODEOXYGLUCOSE</topic><topic>Fluorodeoxyglucose F18</topic><topic>GASTROINTESTINAL TRACT</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>HOURS LIVING RADIOISOTOPES</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Inguinal Canal</topic><topic>INTESTINES</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>LIGHT NUCLEI</topic><topic>Lymph node metastases</topic><topic>LYMPH NODES</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Lymphatic Metastasis - pathology</topic><topic>LYMPHATIC SYSTEM</topic><topic>Male</topic><topic>MEDICINE</topic><topic>METASTASES</topic><topic>Middle Aged</topic><topic>NANOSECONDS LIVING RADIOISOTOPES</topic><topic>Neoplasm Staging - methods</topic><topic>NEOPLASMS</topic><topic>NUCLEAR MEDICINE</topic><topic>NUCLEI</topic><topic>ODD-ODD NUCLEI</topic><topic>ORGANS</topic><topic>PET-CT</topic><topic>POSITRON COMPUTED TOMOGRAPHY</topic><topic>Positron-Emission Tomography - methods</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radiopharmaceuticals</topic><topic>RADIOTHERAPY</topic><topic>Sensitivity and Specificity</topic><topic>Sentinel Lymph Node Biopsy - methods</topic><topic>Sentinel lymph node metastases</topic><topic>Squamous cancer</topic><topic>THERAPY</topic><topic>TOMOGRAPHY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mistrangelo, Massimiliano, Ph.D., M.D</creatorcontrib><creatorcontrib>Pelosi, Ettore, M.D</creatorcontrib><creatorcontrib>Bellò, Marilena, M.D</creatorcontrib><creatorcontrib>Castellano, Isabella, M.D</creatorcontrib><creatorcontrib>Cassoni, Paola, Ph.D., M.D</creatorcontrib><creatorcontrib>Ricardi, Umberto, M.D</creatorcontrib><creatorcontrib>Munoz, Fernando, M.D</creatorcontrib><creatorcontrib>Racca, Patrizia, M.D</creatorcontrib><creatorcontrib>Contu, Viviana, M.D</creatorcontrib><creatorcontrib>Beltramo, Giancarlo, M.D</creatorcontrib><creatorcontrib>Morino, Mario, M.D</creatorcontrib><creatorcontrib>Mussa, Antonio, M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mistrangelo, Massimiliano, Ph.D., M.D</au><au>Pelosi, Ettore, M.D</au><au>Bellò, Marilena, M.D</au><au>Castellano, Isabella, M.D</au><au>Cassoni, Paola, Ph.D., M.D</au><au>Ricardi, Umberto, M.D</au><au>Munoz, Fernando, M.D</au><au>Racca, Patrizia, M.D</au><au>Contu, Viviana, M.D</au><au>Beltramo, Giancarlo, M.D</au><au>Morino, Mario, M.D</au><au>Mussa, Antonio, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Positron Emission Tomography Scanning and Sentinel Node Biopsy in the Detection of Inguinal Node Metastases in Patients With Anal Cancer</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>77</volume><issue>1</issue><spage>73</spage><epage>78</epage><pages>73-78</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Background Inguinal lymph node metastases in patients with anal cancer are an independent prognostic factor for local failure and overall mortality. Inguinal lymph node status can be adequately assessed with sentinel node biopsy, and the radiotherapy strategy can subsequently be changed. We compared this technique vs. dedicated 18F-fluorodeoxyglucose positron emission tomography (PET) to determine which was the better tool for staging inguinal lymph nodes. Methods and Materials In our department, 27 patients (9 men and 18 women) underwent both inguinal sentinel node biopsy and PET-CT. PET-CT was performed before treatment and then at 1 and 3 months after treatment. Results PET-CT scans detected no inguinal metastases in 20 of 27 patients and metastases in the remaining 7. Histologic analysis of the sentinel lymph node detected metastases in only three patients (four PET-CT false positives). HIV status was not found to influence the results. None of the patients negative at sentinel node biopsy developed metastases during the follow-up period. PET-CT had a sensitivity of 100%, with a negative predictive value of 100%. Owing to the high number of false positives, PET-CT specificity was 83%, and positive predictive value was 43%. Conclusions In this series of patients with anal cancer, inguinal sentinel node biopsy was superior to PET-CT for staging inguinal lymph nodes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19632066</pmid><doi>10.1016/j.ijrobp.2009.04.020</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 2010-05, Vol.77 (1), p.73-78 |
| issn | 0360-3016 1879-355X |
| language | eng |
| recordid | cdi_osti_scitechconnect_21372242 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Anal cancer ANTIMETABOLITES Antineoplastic Combined Chemotherapy Protocols - therapeutic use Anus Neoplasms - diagnostic imaging Anus Neoplasms - drug therapy Anus Neoplasms - pathology Anus Neoplasms - radiotherapy BETA DECAY RADIOISOTOPES BETA-PLUS DECAY RADIOISOTOPES BIOPSY BODY Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Combined Modality Therapy - methods COMPUTERIZED TOMOGRAPHY DIAGNOSTIC TECHNIQUES DIGESTIVE SYSTEM DISEASES DRUGS EMISSION COMPUTED TOMOGRAPHY False Positive Reactions Female FLUORINE 18 FLUORINE ISOTOPES FLUORODEOXYGLUCOSE Fluorodeoxyglucose F18 GASTROINTESTINAL TRACT Hematology, Oncology and Palliative Medicine HOURS LIVING RADIOISOTOPES Human immunodeficiency virus Humans Inguinal Canal INTESTINES ISOMERIC TRANSITION ISOTOPES ISOTOPES LIGHT NUCLEI Lymph node metastases LYMPH NODES Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis - diagnosis Lymphatic Metastasis - pathology LYMPHATIC SYSTEM Male MEDICINE METASTASES Middle Aged NANOSECONDS LIVING RADIOISOTOPES Neoplasm Staging - methods NEOPLASMS NUCLEAR MEDICINE NUCLEI ODD-ODD NUCLEI ORGANS PET-CT POSITRON COMPUTED TOMOGRAPHY Positron-Emission Tomography - methods RADIOISOTOPES RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE Radiopharmaceuticals RADIOTHERAPY Sensitivity and Specificity Sentinel Lymph Node Biopsy - methods Sentinel lymph node metastases Squamous cancer THERAPY TOMOGRAPHY |
| title | Comparison of Positron Emission Tomography Scanning and Sentinel Node Biopsy in the Detection of Inguinal Node Metastases in Patients With Anal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T07%3A10%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20Positron%20Emission%20Tomography%20Scanning%20and%20Sentinel%20Node%20Biopsy%20in%20the%20Detection%20of%20Inguinal%20Node%20Metastases%20in%20Patients%20With%20Anal%20Cancer&rft.jtitle=International%20journal%20of%20radiation%20oncology,%20biology,%20physics&rft.au=Mistrangelo,%20Massimiliano,%20Ph.D.,%20M.D&rft.date=2010-05-01&rft.volume=77&rft.issue=1&rft.spage=73&rft.epage=78&rft.pages=73-78&rft.issn=0360-3016&rft.eissn=1879-355X&rft_id=info:doi/10.1016/j.ijrobp.2009.04.020&rft_dat=%3Cproquest_osti_%3E733891495%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733891495&rft_id=info:pmid/19632066&rft_els_id=S0360301609005884&rfr_iscdi=true |