Phase II Trial of Neoadjuvant Bevacizumab, Capecitabine, and Radiotherapy for Locally Advanced Rectal Cancer

Purpose We designed this Phase II trial to assess the efficacy and safety of the addition of bevacizumab to concurrent neoadjuvant capecitabine-based chemoradiation in locally advanced rectal cancer. Methods Between April 2004 and December 2007, 25 patients with clinically staged T3N1 ( n = 20) or T...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2010-03, Vol.76 (3), p.824-830
Hauptverfasser:	Crane, Christopher H., M.D, Eng, Cathy, M.D, Feig, Barry W., M.D, Das, Prajnan, M.D, Skibber, John M., M.D, Chang, George J., M.D, Wolff, Robert A., M.D, Krishnan, Sunil, M.D, Hamilton, Stanley, M.D, Janjan, Nora A., M.D, Maru, Dipen M., M.D, Ellis, Lee M., M.D, Rodriguez-Bigas, Miguel A., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute toxicity Adult Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Antineoplastic Combined Chemotherapy Protocols - therapeutic use ANTINEOPLASTIC DRUGS Bevacizumab BIOLOGICAL RECOVERY BODY Capecitabine Chemoradiation Chemotherapy, Adjuvant - methods Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives DIGESTIVE SYSTEM DISEASES Dose Fractionation, Radiation DRUGS Female Fluorouracil - administration & dosage Fluorouracil - analogs & derivatives Follow-Up Studies GASTROINTESTINAL TRACT HEALING Hematology, Oncology and Palliative Medicine Humans INJURIES INTESTINES LARGE INTESTINE Male MEDICINE Middle Aged Neoadjuvant Neoadjuvant Therapy - adverse effects Neoadjuvant Therapy - methods Neoplasm Staging NEOPLASMS NUCLEAR MEDICINE ORGANS RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Rectal cancer Rectal Neoplasms - drug therapy Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery RECTUM SURGERY Surgical Wound Dehiscence - chemically induced THERAPY TOXICITY WOUNDS
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