Membrane-Dependent Bystander Effect Contributes to Amplification of the Response to Alpha-Particle Irradiation in Targeted and Nontargeted Cells

Purpose Free radicals are believed to play an active role in the bystander response. This study investigated their origin as well as their temporal and spatial impacts in the bystander effect. Methods and Materials We employed a precise alpha-particle microbeam to target a small fraction of subconfl...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2009-11, Vol.75 (4), p.1247-1253
Hauptverfasser:	Hanot, Maïté, Ph.D, Hoarau, Jim, A.S, Carrière, Marie, Ph.D, Angulo, Jaime F., Ph.D, Khodja, Hicham, Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells ALPHA PARTICLES Alpha Particles - therapeutic use Animals BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS Bystander effect Bystander Effect - drug effects Bystander Effect - physiology CELL CONSTITUENTS Cell Membrane - metabolism CELL MEMBRANES CHARGED PARTICLES DNA Breaks, Double-Stranded Filipin - pharmacology Glutathione - metabolism Hematology, Oncology and Palliative Medicine Histones - metabolism Intracellular Signaling Peptides and Proteins - metabolism Ionizing radiation IONIZING RADIATIONS Life Sciences MEMBRANES Mice Microbeam irradiation Micronucleus Tests MITOCHONDRIA Mitochondria - metabolism Osteoblasts - metabolism Osteoblasts - radiation effects Osteoblasts - ultrastructure Oxidative Stress - drug effects RADIATION EFFECTS RADIATIONS Radiology RADIOLOGY AND NUCLEAR MEDICINE Reactive Nitrogen Species - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Tumor Suppressor p53-Binding Protein 1
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