Temporal Patterns of Fatigue Predict Pathologic Response in Patients Treated With Preoperative Chemoradiation Therapy for Rectal Cancer

Purpose To investigate whether symptom burden before and during preoperative chemoradiation therapy (CRT) for rectal cancer predicts for pathologic tumor response. Methods and Materials Fifty-four patients with T3/T4/N+ rectal cancers were treated on a Phase II trial using preoperative capecitabine...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2009-11, Vol.75 (3), p.775-781
Hauptverfasser:	Park, Hee Chul, M.D, Janjan, Nora A., M.D, Mendoza, Tito R., Ph.D, Lin, Edward H., M.D, Vadhan-Raj, Saroj, M.D, Hundal, Mandeep, M.D, Zhang, Yiqun, M.A, Delclos, Marc E., M.D, Crane, Christopher H., M.D, Das, Prajnan, M.D, Wang, Xin Shelley, M.D, Cleeland, Charles S., Ph.D, Krishnan, Sunil, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of Daily Living Adult Aged Antimetabolites, Antineoplastic - therapeutic use BODY Capecitabine COMBINED THERAPY Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use DIGESTIVE SYSTEM DISEASES Down-staging FATIGUE Fatigue - etiology Female Fluorouracil - analogs & derivatives Fluorouracil - therapeutic use GASTROINTESTINAL TRACT Hematology, Oncology and Palliative Medicine Humans INTESTINES LARGE INTESTINE Male MECHANICAL PROPERTIES MEDICINE Middle Aged Neoadjuvant chemoradiation Neoadjuvant Therapy - methods Neoplasm Staging NEOPLASMS NUCLEAR MEDICINE ORGANS PAIN Pain - etiology Prospective Studies RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Rectal cancer Rectal Neoplasms - drug therapy Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy RECTUM Remission Induction Sleep Stages SYMPTOMS THERAPY Tumor response Young Adult
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