In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection
Abstract Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify th...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2009-10, Vol.393 (2), p.221-227 |
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| creator | Desport, Moira Tenaya, I.W. Masa McLachlan, Alexander McNab, Tegan J Rachmat, Judhi Hartaningsih, Nining Wilcox, Graham E |
| description | Abstract Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3+ T-cells or MAC387+ monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus. |
| doi_str_mv | 10.1016/j.virol.2009.07.027 |
| format | Article |
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Masa ; McLachlan, Alexander ; McNab, Tegan J ; Rachmat, Judhi ; Hartaningsih, Nining ; Wilcox, Graham E</creator><creatorcontrib>Desport, Moira ; Tenaya, I.W. Masa ; McLachlan, Alexander ; McNab, Tegan J ; Rachmat, Judhi ; Hartaningsih, Nining ; Wilcox, Graham E</creatorcontrib><description>Abstract Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3+ T-cells or MAC387+ monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2009.07.027</identifier><identifier>PMID: 19733380</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; acute course ; ANIMAL CELLS ; ANIMALS ; Antibodies ; Antibodies, Monoclonal - immunology ; Antibodies, Viral - immunology ; ANTIGENS ; Antigens, Viral - immunology ; BIOLOGICAL MATERIALS ; BLOOD ; BLOOD CELLS ; BODY ; BODY FLUIDS ; Bovine ; Capsid protein ; Capsid Proteins - immunology ; CATTLE ; cattle diseases ; Cattle Diseases - immunology ; Cattle Diseases - virology ; CD3 antigen ; coat proteins ; CONNECTIVE TISSUE CELLS ; DISEASES ; DOMESTIC ANIMALS ; Female ; GLOBULINS ; IgG-containing cells ; immune response ; Immune response (humoral) ; immunoglobulin G ; Immunoglobulin G - immunology ; IMMUNOGLOBULINS ; IMMUNOSUPPRESSION ; IN VIVO ; Infection ; Infectious Disease ; Jembrana disease ; Jembrana disease virus ; Lentivirus ; Lentivirus Infections - immunology ; Lentivirus Infections - veterinary ; Lentivirus Infections - virology ; Lentiviruses, Bovine - immunology ; LEUKOCYTES ; Leukocytes (mononuclear) ; Lung ; Lung - immunology ; Lung - virology ; LUNGS ; lymphocyte proliferation ; LYMPHOCYTES ; Lymphocytes T ; Lymphoid tissue ; Lymphoid Tissue - immunology ; Lymphoid Tissue - virology ; MACROPHAGES ; Macrophages - immunology ; Macrophages - virology ; MAMMALS ; MATERIALS ; MICROORGANISMS ; monoclonal antibodies ; Monocytes ; Monocytes - immunology ; Monocytes - virology ; ORGANIC COMPOUNDS ; ORGANS ; PARASITES ; PATHOGENESIS ; PHAGOCYTES ; PLASMA CELLS ; Plasma Cells - immunology ; Plasma Cells - virology ; PROLIFERATION ; PROTEINS ; RESPIRATORY SYSTEM ; RUMINANTS ; SOMATIC CELLS ; Tropism ; VERTEBRATES ; viral antigens ; VIRUSES</subject><ispartof>Virology (New York, N.Y.), 2009-10, Vol.393 (2), p.221-227</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-77e5aee233a3da087f88277b0434d4c8dae8131124f5cd06bf15b5e79871fa5c3</citedby><cites>FETCH-LOGICAL-c526t-77e5aee233a3da087f88277b0434d4c8dae8131124f5cd06bf15b5e79871fa5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.virol.2009.07.027$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19733380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21357557$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Desport, Moira</creatorcontrib><creatorcontrib>Tenaya, I.W. Masa</creatorcontrib><creatorcontrib>McLachlan, Alexander</creatorcontrib><creatorcontrib>McNab, Tegan J</creatorcontrib><creatorcontrib>Rachmat, Judhi</creatorcontrib><creatorcontrib>Hartaningsih, Nining</creatorcontrib><creatorcontrib>Wilcox, Graham E</creatorcontrib><title>In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Abstract Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3+ T-cells or MAC387+ monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>acute course</subject><subject>ANIMAL CELLS</subject><subject>ANIMALS</subject><subject>Antibodies</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Viral - immunology</subject><subject>ANTIGENS</subject><subject>Antigens, Viral - immunology</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BODY</subject><subject>BODY FLUIDS</subject><subject>Bovine</subject><subject>Capsid protein</subject><subject>Capsid Proteins - immunology</subject><subject>CATTLE</subject><subject>cattle diseases</subject><subject>Cattle Diseases - immunology</subject><subject>Cattle Diseases - virology</subject><subject>CD3 antigen</subject><subject>coat proteins</subject><subject>CONNECTIVE TISSUE CELLS</subject><subject>DISEASES</subject><subject>DOMESTIC ANIMALS</subject><subject>Female</subject><subject>GLOBULINS</subject><subject>IgG-containing cells</subject><subject>immune response</subject><subject>Immune response (humoral)</subject><subject>immunoglobulin G</subject><subject>Immunoglobulin G - immunology</subject><subject>IMMUNOGLOBULINS</subject><subject>IMMUNOSUPPRESSION</subject><subject>IN VIVO</subject><subject>Infection</subject><subject>Infectious Disease</subject><subject>Jembrana disease</subject><subject>Jembrana disease virus</subject><subject>Lentivirus</subject><subject>Lentivirus Infections - immunology</subject><subject>Lentivirus Infections - veterinary</subject><subject>Lentivirus Infections - virology</subject><subject>Lentiviruses, Bovine - immunology</subject><subject>LEUKOCYTES</subject><subject>Leukocytes (mononuclear)</subject><subject>Lung</subject><subject>Lung - immunology</subject><subject>Lung - virology</subject><subject>LUNGS</subject><subject>lymphocyte proliferation</subject><subject>LYMPHOCYTES</subject><subject>Lymphocytes T</subject><subject>Lymphoid tissue</subject><subject>Lymphoid Tissue - immunology</subject><subject>Lymphoid Tissue - virology</subject><subject>MACROPHAGES</subject><subject>Macrophages - immunology</subject><subject>Macrophages - virology</subject><subject>MAMMALS</subject><subject>MATERIALS</subject><subject>MICROORGANISMS</subject><subject>monoclonal antibodies</subject><subject>Monocytes</subject><subject>Monocytes - immunology</subject><subject>Monocytes - virology</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>PARASITES</subject><subject>PATHOGENESIS</subject><subject>PHAGOCYTES</subject><subject>PLASMA CELLS</subject><subject>Plasma Cells - immunology</subject><subject>Plasma Cells - virology</subject><subject>PROLIFERATION</subject><subject>PROTEINS</subject><subject>RESPIRATORY SYSTEM</subject><subject>RUMINANTS</subject><subject>SOMATIC CELLS</subject><subject>Tropism</subject><subject>VERTEBRATES</subject><subject>viral antigens</subject><subject>VIRUSES</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNklGL1DAUhYMo7uzqLxC0IPjW8SZpmvRBQRZ3HVnwYd0XX0Ka3o4ZO8matAPz703twIIv61MS-M7l5JxLyCsKawq0fr9bH1wMw5oBNGuQa2DyCVlRaOoSeEWfkhVAxcpaMXZGzlPaQX5LCc_JGW0k51zBivzY-OLgDqFwvkc7uuCL0Beb7XVpgx-N885vC4vDkIr2WHzFfRuNN0XnEpqEWRqnVHRTnDFjpxEfBr0gz3ozJHx5Oi_I3dXn75dfyptv15vLTzelFaweSylRGETGueGdASV7pZiULVS86iqrOoOKckpZ1QvbQd32VLQCZaMk7Y2w_IK8XeaGNDqdrBvR_szufbahGeVCCiEz9W6h7mP4PWEa9d6l-WPGY5iSrmXdcKHYoyCjFICq-j9AUHWlRAb5AtoYUorY6_vo9iYeNQU9V6l3-m-Veq5Sg9S5yqx6fRo_tXvsHjSn7jLwZgF6E7TZRpf03S0DyrO7iimYHX5YCMzxHxzGOR30FjsX53C64B6x8PEfvR3yRlgz_MIjpl2Yos_NaqoT06Bv532b1w2afBOq4X8AM2fNgQ</recordid><startdate>20091025</startdate><enddate>20091025</enddate><creator>Desport, Moira</creator><creator>Tenaya, I.W. 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Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3+ T-cells or MAC387+ monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19733380</pmid><doi>10.1016/j.virol.2009.07.027</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 60 APPLIED LIFE SCIENCES acute course ANIMAL CELLS ANIMALS Antibodies Antibodies, Monoclonal - immunology Antibodies, Viral - immunology ANTIGENS Antigens, Viral - immunology BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY BODY FLUIDS Bovine Capsid protein Capsid Proteins - immunology CATTLE cattle diseases Cattle Diseases - immunology Cattle Diseases - virology CD3 antigen coat proteins CONNECTIVE TISSUE CELLS DISEASES DOMESTIC ANIMALS Female GLOBULINS IgG-containing cells immune response Immune response (humoral) immunoglobulin G Immunoglobulin G - immunology IMMUNOGLOBULINS IMMUNOSUPPRESSION IN VIVO Infection Infectious Disease Jembrana disease Jembrana disease virus Lentivirus Lentivirus Infections - immunology Lentivirus Infections - veterinary Lentivirus Infections - virology Lentiviruses, Bovine - immunology LEUKOCYTES Leukocytes (mononuclear) Lung Lung - immunology Lung - virology LUNGS lymphocyte proliferation LYMPHOCYTES Lymphocytes T Lymphoid tissue Lymphoid Tissue - immunology Lymphoid Tissue - virology MACROPHAGES Macrophages - immunology Macrophages - virology MAMMALS MATERIALS MICROORGANISMS monoclonal antibodies Monocytes Monocytes - immunology Monocytes - virology ORGANIC COMPOUNDS ORGANS PARASITES PATHOGENESIS PHAGOCYTES PLASMA CELLS Plasma Cells - immunology Plasma Cells - virology PROLIFERATION PROTEINS RESPIRATORY SYSTEM RUMINANTS SOMATIC CELLS Tropism VERTEBRATES viral antigens VIRUSES |
| title | In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection |
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