Immunogenicity and protective efficacy of Semliki forest virus replicon-based DNA vaccines encoding goatpox virus structural proteins

Abstract Goatpox, caused by goatpox virus (GTPV), is an acute feverish and contagious disease in goats often associated with high morbidity and high mortality. To resolve potential safety risks and vaccination side effects of existing live attenuated goatpox vaccine (AV41), two Semliki forest virus...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2009-08, Vol.391 (1), p.33-43
Hauptverfasser:	Zheng, Min, Jin, Ningyi, Liu, Qi, Huo, Xiaowei, Li, Yang, Hu, Bo, Ma, Haili, Zhu, Zhanbo, Cong, Yanzhao, Li, Xiao, Jin, Minglan, Zhu, Guangze
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANIMALS Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Formation Capripoxvirus Capripoxvirus - genetics Capripoxvirus - immunology Cell Proliferation disease control DNA DNA vaccine DOMESTIC ANIMALS goat diseases Goatpox virus GOATS Goats - immunology Goats - virology humoral immunity Immune response IMMUNITY Immunity, Cellular Infectious Disease lymphocyte proliferation MAMMALS MICE Mice, Inbred BALB C MICROORGANISMS Neutralization Tests NUCLEIC ACIDS ORGANIC COMPOUNDS Orthopoxvirus PARASITES Poxviridae Infections - immunology PROTEINS recombinant vaccines replicon Replicon DNA RODENTS RUMINANTS Semliki Forest virus Semliki forest virus - genetics Semliki forest virus - immunology T-Lymphocytes - immunology Vaccination VACCINES Vaccines, DNA - immunology VACCINIA VIRUS VERTEBRATES viral structural proteins Viral Structural Proteins - genetics Viral Structural Proteins - immunology Viral Vaccines - immunology VIRUSES
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