Plasma effects on subcellular structures

Atmospheric pressure helium plasma treated human hepatocytes exhibit distinctive zones of necrotic and live cells separated by a void. We propose that plasma induced necrosis is attributed to plasma species such as oxygen radicals, charged particles, metastables and/or severe disruption of charged c...

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Veröffentlicht in:	Applied physics letters 2010-03, Vol.96 (10), p.101501-101501-3
Hauptverfasser:	Gweon, Bomi, Kim, Daeyeon, Kim, Dan Bee, Jung, Heesoo, Choe, Wonho, Shin, Jennifer H.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANIMAL CELLS ATMOSPHERIC PRESSURE BIOPHYSICS BODY CHARGED PARTICLES DIGESTIVE SYSTEM ELECTRIC FIELDS ELEMENTS FLUIDS GASES GLANDS HELIUM LIVER LIVER CELLS NECROSIS NONMETALS ORGANIC COMPOUNDS ORGANS OXYGEN PATHOLOGICAL CHANGES PHYSICS PLASMA PROTEINS RADICALS RARE GASES SOMATIC CELLS
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container_end_page	101501-3
container_issue	10
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container_title	Applied physics letters
container_volume	96
creator	Gweon, Bomi Kim, Daeyeon Kim, Dan Bee Jung, Heesoo Choe, Wonho Shin, Jennifer H.
description	Atmospheric pressure helium plasma treated human hepatocytes exhibit distinctive zones of necrotic and live cells separated by a void. We propose that plasma induced necrosis is attributed to plasma species such as oxygen radicals, charged particles, metastables and/or severe disruption of charged cytoskeletal proteins. Interestingly, uncharged cytoskeletal intermediate filaments are only minimally disturbed by plasma, elucidating the possibility of plasma induced electrostatic effects selectively destroying charged proteins. These bona fide plasma effects, which inflict alterations in specific subcellular structures leading to necrosis and cellular detachment, were not observed by application of helium flow or electric field alone.
doi_str_mv	10.1063/1.3352316
format	Article
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subjects	60 APPLIED LIFE SCIENCES ANIMAL CELLS ATMOSPHERIC PRESSURE BIOPHYSICS BODY CHARGED PARTICLES DIGESTIVE SYSTEM ELECTRIC FIELDS ELEMENTS FLUIDS GASES GLANDS HELIUM LIVER LIVER CELLS NECROSIS NONMETALS ORGANIC COMPOUNDS ORGANS OXYGEN PATHOLOGICAL CHANGES PHYSICS PLASMA PROTEINS RADICALS RARE GASES SOMATIC CELLS
title	Plasma effects on subcellular structures
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