Effects and uptake of gold nanoparticles deposited at the air–liquid interface of a human epithelial airway model

The impact of nanoparticles (NPs) in medicine and biology has increased rapidly in recent years. Gold NPs have advantageous properties such as chemical stability, high electron density and affinity to biomolecules, making them very promising candidates as drug carriers and diagnostic tools. However,...

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Veröffentlicht in:	Toxicology and applied pharmacology 2010, Vol.242 (1), p.56-65
Hauptverfasser:	Brandenberger, C., Rothen-Rutishauser, B., Mühlfeld, C., Schmid, O., Ferron, G.A., Maier, K.L., Gehr, P., Lenz, A.-G.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AEROSOLS Air–liquid exposure ANIMAL TISSUES ANIMALS Biological and medical sciences Biomarkers BODY CARRIERS CELL CULTURES Cell Line Chemical and industrial products toxicology. Toxic occupational diseases Coculture Techniques COLLOIDS Cytokines - analysis Cytokines - biosynthesis DIAGNOSTIC TECHNIQUES DISPERSIONS DRUGS ELECTRON MICROSCOPY ELEMENTS EPITHELIUM GOLD Gold - pharmacokinetics Gold - pharmacology Gold nanoparticles Human epithelial airway model Humans Inflammation - metabolism LUNGS MALES MAMMALS MAN Medical sciences MEDICINE MEN MESSENGER-RNA METALS Metals and various inorganic compounds MICROSCOPY Microscopy, Electron, Transmission Nanoparticles NANOSTRUCTURES Nanotoxicology NUCLEIC ACIDS ORGANIC COMPOUNDS ORGANS Oxidative Stress - drug effects Particle lung interaction Particle Size PARTICLES PRIMATES Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism RESPIRATORY SYSTEM Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Messenger - biosynthesis SOLS Toxicology TRANSITION ELEMENTS TRANSMISSION ELECTRON MICROSCOPY VERTEBRATES
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