Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure

Arsenic, a human carcinogen that is associated with an increased risk of bladder cancer, is commonly found in drinking water. An important mechanism by which arsenic is thought to be carcinogenic is through the induction of epigenetic changes that lead to aberrant gene expression. Previously, we rep...

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Veröffentlicht in:	Toxicology and applied pharmacology 2009-12, Vol.241 (3), p.294-302
Hauptverfasser:	Jo, William Jaime, Ren, Xuefeng, Chu, Feixia, Aleshin, Maria, Wintz, Henri, Burlingame, Alma, Smith, Martyn Thomas, Vulpe, Chris Dillon, Zhang, Luoping
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACETYLATION ACYLATION AMINO ACIDS ANIMAL TISSUES ANIMALS ARSENIC Arsenicals Biological and medical sciences BLADDER Bladder cancer Blotting, Western BODY CARBOXYLIC ACIDS CARCINOGENESIS Carcinogenesis, carcinogens and anticarcinogens CARCINOGENS Chemical agents Chemical and industrial products toxicology. Toxic occupational diseases CHEMICAL REACTIONS CHROMATIN Chromatin - physiology Coloring Agents DISEASES Dose-Response Relationship, Drug DOSES DRINKING WATER ELEMENTS Epigenetics Epithelial Cells - drug effects Epithelial Cells - metabolism EPITHELIUM EUMYCOTA FUNGI Gene Silencing - drug effects GENES H4K16 Histone acetylation Histone Acetyltransferases - metabolism Histone Acetyltransferases - physiology Humans HYDROGEN COMPOUNDS LYSINE MALES MAMMALS MAN Mass Spectrometry Medical sciences MEN Metals and various inorganic compounds MICROORGANISMS NEOPLASMS Nephrology. Urinary tract diseases ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS OXYGEN COMPOUNDS PATHOGENESIS PLANTS PRIMATES Retroviridae - genetics Reverse Transcriptase Polymerase Chain Reaction RNAi Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - growth & development SEMIMETALS SENSITIVITY Tetrazolium Salts Thiazoles TOXICITY Toxicology Tumors Tumors of the urinary system Urinary Bladder - cytology Urinary Bladder - drug effects Urinary Bladder - metabolism Urinary system involvement in other diseases. Miscellaneous URINARY TRACT Urinary tract. Prostate gland VERTEBRATES WATER Yeast YEASTS
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