Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure

Titanium dioxide (TiO2) nano-particles (< 100 nm in diameter) have been of interest in a wide range of applications, such as in cosmetics and pharmaceuticals because of their low toxicity. However, recent studies have shown that TiO2 nano-particles (nano-TiO2) induce cytotoxicity and genotoxicity...

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Veröffentlicht in:	Toxicology and applied pharmacology 2009-12, Vol.241 (2), p.182-194
Hauptverfasser:	Huang, Shing, Chueh, Pin Ju, Lin, Yun-Wei, Shih, Tung-Sheng, Chuang, Show-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy ANIMAL CELLS Animals Cell Cycle Proteins - metabolism CELL DIVISION CELL PROLIFERATION Cell Proliferation - drug effects Cell Survival - drug effects Cell Transformation, Neoplastic - chemically induced Cell Transformation, Neoplastic - pathology CELL TRANSFORMATIONS CHALCOGENIDES Chromosome Segregation CONNECTIVE TISSUE CELLS Cytotoxicity Cytotoxins - administration & dosage Cytotoxins - chemistry Cytotoxins - toxicity DNA Damage - drug effects Dose-Response Relationship, Drug Drug Administration Schedule Extracellular Signal-Regulated MAP Kinases - physiology FIBROBLASTS Genotoxicity Mice MITOSIS Mitosis - drug effects Nano-particles Nanoparticles NANOSCIENCE AND NANOTECHNOLOGY NANOSTRUCTURES NIH 3T3 Cells OXIDES OXYGEN COMPOUNDS PARTICLES PLK1 Polo-Like Kinase 1 Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Reactive Oxygen Species - metabolism SEGREGATION SOMATIC CELLS TiO2 Titanium - administration & dosage Titanium - chemistry Titanium - toxicity TITANIUM COMPOUNDS TITANIUM OXIDES TOXICITY TRANSITION ELEMENT COMPOUNDS
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