Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists

C-reactive protein (CRP), a human acute-phase protein, is a risk factor for future cardiovascular events and exerts direct pro-inflammatory and pro-atherogenic properties. The farnesoid X receptor (FXR), a member of the nuclear hormone receptor superfamily, plays an essential role in the regulation...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-02, Vol.379 (2), p.476-479
Hauptverfasser:	Zhang, Songwen, Liu, Qiangyuan, Wang, Juan, Harnish, Douglas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acute-Phase Reaction - genetics Acute-Phase Reaction - immunology Animals C-reactive protein C-Reactive Protein - antagonists & inhibitors C-Reactive Protein - biosynthesis Cell Line, Tumor DNA-Binding Proteins - agonists DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Farnesoid X receptor (FXR) agonist Gene Expression - drug effects GLOBULINS GW4064 HEPATOMAS HOMEOSTASIS HORMONES HUMAN POPULATIONS Humans IMMUNITY INFLAMMATION Interleukin-6 - pharmacology Interleukin-6 - physiology LIVER LYMPHOKINES MICE Mice, Inbred C57BL RECEPTORS Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology RNA RNA, Small Interfering - genetics Transcription Factors - agonists Transcription Factors - genetics Transcription Factors - physiology WAY-362450
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