In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(–PEG)/siRNA complexes

RNA interference (RNAi) represents a novel therapeutic strategy allowing the knockdown of any pathologically relevant target gene. Since it relies on the action of small interfering RNAs (siRNAs), the in vivo delivery of siRNAs is instrumental. Polyethylenimines (PEIs) and PEGylated PEIs have been s...

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Veröffentlicht in:	Toxicology and applied pharmacology 2009-04, Vol.236 (1), p.97-108
Hauptverfasser:	Malek, Anastasia, Merkel, Olivia, Fink, Ludger, Czubayko, Frank, Kissel, Thomas, Aigner, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Biodistribution Biological and medical sciences Biotransformation COMPLEXES COPOLYMERS Erythrocyte Aggregation - drug effects ERYTHROCYTES Gene Transfer Techniques HEMORRHAGE Hemorrhage - etiology IN VIVO In vivo pharmacokinetics Injections, Intravenous Kidney - metabolism KIDNEYS LIVER Liver - metabolism Lung - metabolism LUNGS MACROPHAGES Macrophages - metabolism Male Medical sciences MICE Mice, Inbred C57BL PEI–PEG Polyethylene Glycols - chemistry Polyethyleneimine - chemistry Polyethylenimine RNA RNA Interference RNA, Small Interfering - administration & dosage RNA, Small Interfering - adverse effects RNA, Small Interfering - chemistry RNA, Small Interfering - pharmacokinetics RNAi siRNAs SPLEEN Spleen - metabolism TISSUE DISTRIBUTION Toxicology
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