Toxicodynamic analysis of the inhibition of isolated human acetylcholinesterase by combinations of methamidophos and methomyl in vitro

The applicability of dose addition to combinations of OP-esters and carbamates has been questioned based on theoretical considerations, but these have not been well supported by experimental findings. In the present study, the inhibition of AChE by combinations of methamidophos (an OP-ester) and met...

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Veröffentlicht in:	Toxicology and applied pharmacology 2009-04, Vol.236 (1), p.1-8
Hauptverfasser:	Bosgra, Sieto, van Eijkeren, Jan C.H., van der Schans, Marcel J., Langenberg, Jan P., Slob, Wout
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acetylcholinesterase - metabolism Biological and medical sciences CARBAMATES CHOLINESTERASE Cholinesterase inhibition Cholinesterase Inhibitors - toxicity Dose additivity Dose-Response Relationship, Drug DOSES Drug Interactions Ellman assay ESTERS Humans IN VITRO INHIBITION Insecticides - toxicity Interaction Kinetics Medical sciences Methomyl - toxicity Mixture Models, Biological N-methyl carbamates Organophosphorus pesticides Organothiophosphorus Compounds - toxicity PESTICIDES Pesticides, fertilizers and other agrochemicals toxicology Phosphorylation Reproducibility of Results Risk Assessment Toxicology
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