Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

The aim of this study was to determine whether primary human tubular cell monolayers could provide a powerful tool with which to investigate the renal proximal tubular handling of xenobiotics. Human proximal and distal tubule/collecting duct cells were grown as monolayers on permeable filter support...

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Veröffentlicht in:	Toxicology and applied pharmacology 2008-12, Vol.233 (3), p.428-438
Hauptverfasser:	Brown, Colin D.A., Sayer, Rachel, Windass, Amy S., Haslam, Iain S., De Broe, Marc E., D'Haese, Patrick C., Verhulst, Anja
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ABC transporters ANIONS ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences CATIONS Cells, Cultured CREATININE Creatinine - metabolism Epithelial Cells - drug effects Epithelial Cells - metabolism Fluorescent Antibody Technique Humans Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism Medical sciences MEMBRANES Models, Biological Organic anion transporters Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Organic cation transporters POLYCYCLIC AROMATIC HYDROCARBONS Protein Transport PROTEINS Proximal tubule Renal xenobiotic secretion Reverse Transcriptase Polymerase Chain Reaction SECRETION SUBSTRATES Toxicology TUBULES XENOBIOTICS Xenobiotics - pharmacokinetics Xenobiotics - toxicity
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