The LIM-homeodomain transcription factor LMX1B regulates expression of NF-kappa B target genes

LMX1B is a LIM-homeodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies, but their identity as direct LMX1B targets remains hypothetical. We describe here the first molecular characterization of LMX1B target gen...

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Veröffentlicht in:	Experimental cell research 2009, Vol.315 (1), p.76-96
Hauptverfasser:	Rascle, Anne, Neumann, Tanja, Raschta, Anne-Sarah, Neumann, Astrid, Heining, Eva, Kastner, Juergen, Witzgall, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Base Sequence Cellular biology ChIP assay CHROMATIN Conserved Sequence DNA Gene expression Gene expression profiling Gene Expression Regulation GENE REGULATION GENES HELA CELLS Homeodomain Proteins - chemistry Homeodomain Proteins - metabolism Humans IN VIVO INHIBITION Interferon-beta - pharmacology Interleukin-6 - genetics Interleukin-8 - genetics Kidney - metabolism KIDNEYS Knock-out mouse LIM-Homeodomain Proteins LMX1B LUCIFERASE Luciferase reporter assay MICE Mice, Knockout Molecular Sequence Data NF-kappa B - metabolism NF-κB Promoter Regions, Genetic PROMOTERS Protein Binding - drug effects Protein Structure, Tertiary Ribonucleic acid RNA Rodents siRNA-mediated knock-down Sus scrofa Tet-off expression system TETRACYCLINES TRANSCRIPTION Transcription Factor RelA - metabolism TRANSCRIPTION FACTORS Transcription Factors - chemistry Transcription Factors - metabolism Transcription, Genetic - drug effects Transcriptional Activation - drug effects Up-Regulation - drug effects
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