Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain

HMGB1 is an evolutionarily conserved non-histone chromatin-associated protein with key roles in maintenance of nuclear homeostasis; however, the function of HMGB1 in the brain remains largely unknown. Recently, we found that the reduction of nuclear HMGB1 protein level in the nucleus associates with...

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Veröffentlicht in:Biochemical and biophysical research communications 2008-11, Vol.376 (1), p.128-133
Hauptverfasser: Enokido, Yasushi, Yoshitake, Ayaka, Ito, Hikaru, Okazawa, Hitoshi
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Sprache:eng
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