Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats

Hexavalent chromium (Cr-VI) is used in a wide range of industries. Cr-VI from chromate industries and atmospheric emissions contribute to the Cr contamination in the environment. Cr is a reproductive metal toxicant that can traverse the placental barrier and cause a wide range of fetal effects inclu...

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Veröffentlicht in:	Toxicology and applied pharmacology 2008-10, Vol.232 (2), p.180-189
Hauptverfasser:	Banu, Sakhila K., Samuel, Jawahar B., Arosh, Joe A., Burghardt, Robert C., Aruldhas, Michael M.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Age Factors Animals Animals, Newborn ASCORBIC ACID Ascorbic Acid - administration & dosage Biological and medical sciences Cell Line Chemical and industrial products toxicology. Toxic occupational diseases CHROMATES CHROMIUM Chromium (VI) Chromium - administration & dosage Chromium - toxicity DICHROMATES DIET DRINKING WATER ESTROUS CYCLE Female FSH Gonadal Steroid Hormones - antagonists & inhibitors Gonadal Steroid Hormones - biosynthesis Gonadal Steroid Hormones - genetics Gynecology. Andrology. Obstetrics IN VITRO IN VIVO Lactation - blood Medical sciences Metals and various inorganic compounds MILK OVARIES Ovary Ovary - drug effects Ovary - growth & development Ovary - metabolism Pituitary Hormones - antagonists & inhibitors Pituitary Hormones - biosynthesis Pituitary Hormones - genetics POTASSIUM Pregnancy Puberal and climacteric disorders (male and female) Puberty RATS Rats, Wistar Sexual Maturation - drug effects Sexual Maturation - physiology Steroidogenesis TOXICITY Toxicology
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