Novel function of glutathione transferase in rat liver mitochondrial membrane : Role for cytochrome c release from mitochondria

Microsomal glutathione transferase (MGST1) is activated by oxidative stress. Although MGST1 is found in mitochondrial membranes (mtMGST1), there is no information about the oxidative activation of mtMGST1. In the present study, we aimed to determine whether mtMGST1 also undergoes activation and abou...

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Veröffentlicht in:	Toxicology and applied pharmacology 2008-10, Vol.232 (1), p.109-118
Hauptverfasser:	KANG KWANG LEE, SHIMOJI, Manami, HOSSAIN, Quazi Sohel, SUNAKAWA, Hajime, ANIYA, Yoko
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ADENINES Animals ANIONS ANTIBODIES APOPTOSIS Biological and medical sciences Blotting, Western Bongkrekic Acid - pharmacology Cyclosporine - pharmacology Cytochromes c - metabolism Diamide - pharmacology Dimerization DIMERS DISULFIDES Disulfides - metabolism Dithiothreitol - pharmacology DTPA ELECTRIC POTENTIAL Enzyme Activation Galactosamine - administration & dosage GLUTATHIONE Glutathione - metabolism Glutathione Transferase - metabolism IN VITRO Lipopolysaccharides - administration & dosage LIVER Male Medical sciences MITOCHONDRIA Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Mitochondria, Liver - pathology Mitochondrial Membrane Transport Proteins - antagonists & inhibitors Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Membranes - drug effects Mitochondrial Membranes - enzymology Mitochondrial Swelling NUCLEOTIDES OXIDATION Oxidation-Reduction Oxidative Stress PERMEABILITY RATS Rats, Sprague-Dawley REDUCING AGENTS Reducing Agents - pharmacology SODIUM Sulfhydryl Reagents - pharmacology SWELLING Time Factors Toxicology Tyrosine - analogs & derivatives Tyrosine - metabolism
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