A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells

Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. In injured liver they are the main extracellular matrix protein producing cell type and further perpetuate hepatic injury by secretion of pro-inflammatory mediators. Since LPS-mediated signaling through toll-like recept...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-10, Vol.375 (2), p.210-214
Hauptverfasser:	Schnabl, Bernd, Brandl, Katharina, Fink, Marina, Gross, Philipp, Taura, Kojiro, Gäbele, Erwin, Hellerbrand, Claus, Falk, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Cells, Cultured Chemokines - antagonists & inhibitors Chemokines - biosynthesis FIBROSIS GROWTH FACTORS Hepatic stellate cells Humans Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - therapeutic use Immunoglobulin G - genetics Immunoglobulin G - therapeutic use IN VIVO INFLAMMATION INJURIES LIGANDS Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - immunology LIVER Liver Cirrhosis - drug therapy Liver Cirrhosis - immunology Liver fibrosis LPS Lymphocyte Antigen 96 - genetics Lymphocyte Antigen 96 - therapeutic use MAP Kinase Kinase 4 - metabolism MICE MONOCYTES MUTANTS NF-kappa B - metabolism Protein Structure, Tertiary - genetics RECEPTORS Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - therapeutic use SECRETION Signal Transduction Toll-like receptor Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - therapeutic use
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