A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

SIRT1, which belongs to the family of type III histone deacetylase, is implicated in diverse cellular processes. We have determined the expression levels of SIRT1 in human prostate cancer cell lines and have examined the roles of SIRT1 in cell growth and chemoresistance. SIRT1 expression was markedl...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-08, Vol.373 (3), p.423-428
Hauptverfasser:	Kojima, Keitaro, Ohhashi, Riyako, Fujita, Yasunori, Hamada, Nanako, Akao, Yukihiro, Nozawa, Yoshinori, Deguchi, Takashi, Ito, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Androgen-refractory ANDROGENS Androgens - metabolism Antineoplastic Agents - pharmacology Benzamides - pharmacology Camptothecin Camptothecin - pharmacology Cell Line, Tumor CELL PROLIFERATION Cell Proliferation - drug effects Chemoresistance Cisplatin Cisplatin - pharmacology Drug Resistance, Neoplasm - drug effects DU145 GENE REGULATION Humans Male Naphthols - pharmacology NEOPLASMS PC3 PROSTATE Prostate cancer Prostatic Neoplasms - enzymology SENSITIVITY SiRNA SIRT1 Sirtinol Sirtuin 1 Sirtuins - antagonists & inhibitors Sirtuins - genetics Sirtuins - metabolism Up-Regulation
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