Immunotoxicity of aflatoxin B1: Impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression

Aflatoxin B1 (AFB1), a mycotoxin produced by Aspergillus flavus or A. parasiticus, is a frequent contaminant of food and feed. This toxin is hepatotoxic and immunotoxic. The present study analyzed in pigs the influence of AFB1 on humoral and cellular responses, and investigated whether the immunomod...

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Veröffentlicht in:	Toxicology and applied pharmacology 2008-09, Vol.231 (2), p.142-149
Hauptverfasser:	Meissonnier, Guylaine M., Pinton, Philippe, Laffitte, Joëlle, Cossalter, Anne-Marie, Gong, Yun Yun, Wild, Christopher P., Bertin, Gérard, Galtier, Pierre, Oswald, Isabelle P.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Aflatoxin B1 Aflatoxin B1 - administration & dosage Aflatoxin B1 - toxicity AFLATOXINS ALBUMINS Animals Antibody Formation - drug effects ASPERGILLUS Aspergillus flavus Aspergillus parasiticus Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Cytokines Cytokines - drug effects Cytokines - metabolism Dose-Response Relationship, Drug DOSES Gene Expression Regulation - drug effects Immunity, Cellular - drug effects Immunoglobulin Isotypes - drug effects Immunoglobulin Isotypes - metabolism Immunotoxins - administration & dosage Immunotoxins - toxicity INFLAMMATION Life Sciences LYMPHOCYTES Lymphocytes - drug effects Lymphocytes - metabolism LYMPHOKINES Male Medical sciences Mitogens - metabolism OVALBUMIN Ovalbumin - immunology Plant poisons toxicology POLYMERASE CHAIN REACTION Real-time PCR SPLEEN Spleen - metabolism SWINE Toxicology Tumors Vaccination VACCINES Vaccines - immunology
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