Cytogenetic status and oxidative DNA-damage induced by atorvastatin in human peripheral blood lymphocytes: Standard and Fpg-modified comet assay

To investigate the genotoxic potential of atorvastatin on human lymphocytes in vitro standard comet assay was used in the evaluation of basal DNA damage and to investigate possible oxidative DNA damage produced by reactive oxygen species (ROS) Fpg-modified version of comet assay was also conducted....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology and applied pharmacology 2008-08, Vol.231 (1), p.85-93
Hauptverfasser:	Gajski, Goran, Garaj-Vrhovac, Vera, Oreščanin, Višnja
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adult Atorvastatin Atorvastatin Calcium Biological and medical sciences Cell Survival Comet Assay Cytogenetics DNA DNA Damage DNA DAMAGES DNA-Formamidopyrimidine Glycosylase - genetics Fpg-modified comet assay Heptanoic Acids - toxicity Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity IN VITRO In Vitro Techniques LYMPHOCYTES Lymphocytes - drug effects Male Medical sciences Micronucleus test Micronucleus Tests Mutagenicity Tests OXIDATION Oxidation-Reduction Oxidative DNA-damage Oxidative Stress Peripheral blood human lymphocytes Pyrroles - toxicity REGRESSION ANALYSIS Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!