An underlying role for hepatobiliary dysfunction in cyclosporine A nephrotoxicity

Renal-derived cysteinyl leukotrienes (cysLT), such as leukotrienes C 4 (LTC 4) and D 4 (LTD 4) are thought to mediate acute and chronic cyclosporine A (CSA) nephrotoxicity. However, whole-body cysLT elimination is regulated primarily by hepatobiliary excretion. Since CSA is known to alter hepatobili...

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Veröffentlicht in:	Toxicology and applied pharmacology 2008-07, Vol.230 (1), p.126-134
Hauptverfasser:	Aleo, Michael D., Doshna, Colleen M., Fritz, Carol A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals BILE BILIARY TRACT Biliary Tract - drug effects Biliary Tract - metabolism Biological and medical sciences BLADDER BLOOD BUILDUP CYCLOSPORINE Cyclosporine - toxicity Cyclosporine A DOSES EXCRETION GFR Glomerular filtration rate Glomerular Filtration Rate - drug effects GLYCEROL Hepatic Hepatobiliary Immunosuppressive Agents - toxicity IN VIVO Kidney - drug effects Kidney - metabolism KIDNEYS Leukotriene Leukotriene C4 - metabolism LIVER Liver - drug effects Liver - metabolism LTC 4 LTD 4, Thromboxane Male Medical sciences Nephrotoxicity RATS Rats, Sprague-Dawley Renal Thromboxanes - biosynthesis TOXICITY Toxicology TRITIUM TXA 2 TXB 2 URINE
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