Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: Involvement of Src/EGFR/PI3-K/Akt pathway

In our previous study, LPS has been shown to induce vascular cell adhesion molecule-1(VCAM-1) expression through MAPKs and NF-κB in human tracheal smooth muscle cells (HTSMCs). In addition to these pathways, the non-receptor tyrosine kinases (Src), EGF receptor (EGFR), and phosphatidylinositol 3-kin...

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Veröffentlicht in:	Toxicology and applied pharmacology 2008-04, Vol.228 (2), p.256-268
Hauptverfasser:	Lin, Wei-Ning, Luo, Shue-Fen, Wu, Chou-Bing, Lin, Chih-Chung, Yang, Chuen-Mao
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Akt Androstadienes - pharmacology Blotting, Western Cell Adhesion - drug effects Cell Line CHROMATIN Chromones - pharmacology CURCUMIN Dose-Response Relationship, Drug E1A-Associated p300 Protein - genetics E1A-Associated p300 Protein - metabolism EGFR HTSMCs Humans INFLAMMATION Lipopolysaccharides - pharmacology LPS MOLECULES Morpholines - pharmacology MUSCLES Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism NEUTROPHILS Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism p300 Phosphatidylinositol 3-Kinases - metabolism PHOSPHORYLATION Phosphorylation - drug effects PHOSPHOTRANSFERASES PROMOTERS Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Quinazolines Receptor, Epidermal Growth Factor - metabolism RECEPTORS Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics Signal Transduction - drug effects Src src-Family Kinases - metabolism Trachea - cytology Transfection TYROSINE Tyrphostins - pharmacology Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism VCAM-1
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