Comparison of IMRT Treatment Plans Between Linac and Helical Tomotherapy Based on Integral Dose and Inhomogeneity Index
Abstract Intensity modulated radiotherapy (IMRT) is an advanced treatment technology for radiation therapy. There are several treatment planning systems (TPS) that can generate IMRT plans. These plans may show different inhomogeneity indices to the planning target volume (PTV) and integral dose to o...
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| Veröffentlicht in: | Medical dosimetry : official journal of the American Association of Medical Dosimetrists 2008, Vol.33 (3), p.215-221 |
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| creator | Shi, Chengyu, Ph.D Peñagarícano, Jose, M.D Papanikolaou, Niko, Ph.D |
| description | Abstract Intensity modulated radiotherapy (IMRT) is an advanced treatment technology for radiation therapy. There are several treatment planning systems (TPS) that can generate IMRT plans. These plans may show different inhomogeneity indices to the planning target volume (PTV) and integral dose to organs at risk (OAR). In this study, we compared clinical cases covering different anatomical treatment sites, including head and neck, brain, lung, prostate, pelvis, and cranio-spinal axis. Two treatment plans were developed for each case using Pinnacle3 and helical tomotherapy (HT) TPS. The inhomogeneity index of the PTV and the non-tumor integral dose (NTID) were calculated and compared for each case. Despite the difference in the number of effective beams, in several cases, NTID did not increase from HT as compared to the step-and-shoot delivery method. Six helical tomotherapy treatment plans for different treatment sites have been analyzed and compared against corresponding step-and-shoot plans generated with the Pinnacle3 planning system. Results show that HT may produce plans with smaller integral doses to healthy organs, and fairly homogeneous doses to the target as compared to linac-based step-and-shoot IMRT planning in special treatment site such as cranio-spinal. |
| doi_str_mv | 10.1016/j.meddos.2007.11.001 |
| format | Article |
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There are several treatment planning systems (TPS) that can generate IMRT plans. These plans may show different inhomogeneity indices to the planning target volume (PTV) and integral dose to organs at risk (OAR). In this study, we compared clinical cases covering different anatomical treatment sites, including head and neck, brain, lung, prostate, pelvis, and cranio-spinal axis. Two treatment plans were developed for each case using Pinnacle3 and helical tomotherapy (HT) TPS. The inhomogeneity index of the PTV and the non-tumor integral dose (NTID) were calculated and compared for each case. Despite the difference in the number of effective beams, in several cases, NTID did not increase from HT as compared to the step-and-shoot delivery method. Six helical tomotherapy treatment plans for different treatment sites have been analyzed and compared against corresponding step-and-shoot plans generated with the Pinnacle3 planning system. Results show that HT may produce plans with smaller integral doses to healthy organs, and fairly homogeneous doses to the target as compared to linac-based step-and-shoot IMRT planning in special treatment site such as cranio-spinal.</description><identifier>ISSN: 0958-3947</identifier><identifier>EISSN: 1873-4022</identifier><identifier>DOI: 10.1016/j.meddos.2007.11.001</identifier><identifier>PMID: 18674686</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Aged ; BEAMS ; Body Burden ; BRAIN ; Brain Neoplasms - radiotherapy ; CARCINOMAS ; COMPUTERIZED TOMOGRAPHY ; CT-GUIDED RADIOTHERAPY ; Decision Support Systems, Clinical ; Dose-Response Relationship, Radiation ; Female ; HEAD ; Head and Neck Neoplasms - radiotherapy ; Hematology, Oncology and Palliative Medicine ; Humans ; IMRT ; Inhomogeneity index ; Integral dose ; INTEGRAL DOSES ; LINEAR ACCELERATORS ; Lung Neoplasms - radiotherapy ; LUNGS ; Male ; Middle Aged ; NECK ; Pelvic Neoplasms - radiotherapy ; PELVIS ; PROSTATE ; Prostatic Neoplasms - radiotherapy ; Radiation Tolerance ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiology Information Systems ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Intensity-Modulated - methods ; Relative Biological Effectiveness ; Spinal Neoplasms - radiotherapy ; Tomography, Spiral Computed ; Tomotherapy ; Weights and Measures</subject><ispartof>Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 2008, Vol.33 (3), p.215-221</ispartof><rights>American Association of Medical Dosimetrists</rights><rights>2008 American Association of Medical Dosimetrists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-4657567ce7c8362f6423782204c5f7efe9be318499471cfe62f5e194598b83673</citedby><cites>FETCH-LOGICAL-c443t-4657567ce7c8362f6423782204c5f7efe9be318499471cfe62f5e194598b83673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.meddos.2007.11.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18674686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21140789$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Chengyu, Ph.D</creatorcontrib><creatorcontrib>Peñagarícano, Jose, M.D</creatorcontrib><creatorcontrib>Papanikolaou, Niko, Ph.D</creatorcontrib><title>Comparison of IMRT Treatment Plans Between Linac and Helical Tomotherapy Based on Integral Dose and Inhomogeneity Index</title><title>Medical dosimetry : official journal of the American Association of Medical Dosimetrists</title><addtitle>Med Dosim</addtitle><description>Abstract Intensity modulated radiotherapy (IMRT) is an advanced treatment technology for radiation therapy. There are several treatment planning systems (TPS) that can generate IMRT plans. These plans may show different inhomogeneity indices to the planning target volume (PTV) and integral dose to organs at risk (OAR). In this study, we compared clinical cases covering different anatomical treatment sites, including head and neck, brain, lung, prostate, pelvis, and cranio-spinal axis. Two treatment plans were developed for each case using Pinnacle3 and helical tomotherapy (HT) TPS. The inhomogeneity index of the PTV and the non-tumor integral dose (NTID) were calculated and compared for each case. Despite the difference in the number of effective beams, in several cases, NTID did not increase from HT as compared to the step-and-shoot delivery method. Six helical tomotherapy treatment plans for different treatment sites have been analyzed and compared against corresponding step-and-shoot plans generated with the Pinnacle3 planning system. Results show that HT may produce plans with smaller integral doses to healthy organs, and fairly homogeneous doses to the target as compared to linac-based step-and-shoot IMRT planning in special treatment site such as cranio-spinal.</description><subject>Adolescent</subject><subject>Aged</subject><subject>BEAMS</subject><subject>Body Burden</subject><subject>BRAIN</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>CARCINOMAS</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>CT-GUIDED RADIOTHERAPY</subject><subject>Decision Support Systems, Clinical</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>HEAD</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>IMRT</subject><subject>Inhomogeneity index</subject><subject>Integral dose</subject><subject>INTEGRAL DOSES</subject><subject>LINEAR ACCELERATORS</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>LUNGS</subject><subject>Male</subject><subject>Middle Aged</subject><subject>NECK</subject><subject>Pelvic Neoplasms - radiotherapy</subject><subject>PELVIS</subject><subject>PROSTATE</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Radiation Tolerance</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiology Information Systems</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>Relative Biological Effectiveness</subject><subject>Spinal Neoplasms - radiotherapy</subject><subject>Tomography, Spiral Computed</subject><subject>Tomotherapy</subject><subject>Weights and Measures</subject><issn>0958-3947</issn><issn>1873-4022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVGL1DAQx4Mo3nr6DUQCPrdO0rRpXwRvT72FFUXX55BNp7dZ22RJcp777U3tgeCLTyHk95_M_IaQlwxKBqx5cywn7HsfSw4gS8ZKAPaIrFgrq0IA54_JCrq6LapOyAvyLMYjANQCqqfkgrWNFE3brMj92k8nHWz0jvqBbj593dFdQJ0mdIl-GbWL9ArTPaKjW-u0odr19AZHa_RId37y6YBBn870SkfsaS6zcQlvQ3699hH_4Bt3yOAtOrTpnG89_npOngx6jPji4bwk3z-8361viu3nj5v1u21hhKhSIZpa1o00KE1bNXxoBK9kyzkIUw8SB-z2WLFWdHlIZgbMSI2sE3XX7nNAVpfk9VLXx2RVNDahORjvHJqkOGMCZNtlSiyUCT7GgIM6BTvpcFYM1GxbHdViW822FWMq286xV0vsdLfPz39DD3oz8HYBMI_402KYO0BnsLdhbqD39n8__FvAjNbN7n_gGePR3wWX9SmmIlegvs0bnxcOEoAz3lW_ATsGpjc</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Shi, Chengyu, Ph.D</creator><creator>Peñagarícano, Jose, M.D</creator><creator>Papanikolaou, Niko, Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>2008</creationdate><title>Comparison of IMRT Treatment Plans Between Linac and Helical Tomotherapy Based on Integral Dose and Inhomogeneity Index</title><author>Shi, Chengyu, Ph.D ; Peñagarícano, Jose, M.D ; Papanikolaou, Niko, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-4657567ce7c8362f6423782204c5f7efe9be318499471cfe62f5e194598b83673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Aged</topic><topic>BEAMS</topic><topic>Body Burden</topic><topic>BRAIN</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>CARCINOMAS</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>CT-GUIDED RADIOTHERAPY</topic><topic>Decision Support Systems, Clinical</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Female</topic><topic>HEAD</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>IMRT</topic><topic>Inhomogeneity index</topic><topic>Integral dose</topic><topic>INTEGRAL DOSES</topic><topic>LINEAR ACCELERATORS</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>LUNGS</topic><topic>Male</topic><topic>Middle Aged</topic><topic>NECK</topic><topic>Pelvic Neoplasms - radiotherapy</topic><topic>PELVIS</topic><topic>PROSTATE</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Radiation Tolerance</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radiology Information Systems</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>Relative Biological Effectiveness</topic><topic>Spinal Neoplasms - radiotherapy</topic><topic>Tomography, Spiral Computed</topic><topic>Tomotherapy</topic><topic>Weights and Measures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Chengyu, Ph.D</creatorcontrib><creatorcontrib>Peñagarícano, Jose, M.D</creatorcontrib><creatorcontrib>Papanikolaou, Niko, Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Medical dosimetry : official journal of the American Association of Medical Dosimetrists</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Chengyu, Ph.D</au><au>Peñagarícano, Jose, M.D</au><au>Papanikolaou, Niko, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of IMRT Treatment Plans Between Linac and Helical Tomotherapy Based on Integral Dose and Inhomogeneity Index</atitle><jtitle>Medical dosimetry : official journal of the American Association of Medical Dosimetrists</jtitle><addtitle>Med Dosim</addtitle><date>2008</date><risdate>2008</risdate><volume>33</volume><issue>3</issue><spage>215</spage><epage>221</epage><pages>215-221</pages><issn>0958-3947</issn><eissn>1873-4022</eissn><abstract>Abstract Intensity modulated radiotherapy (IMRT) is an advanced treatment technology for radiation therapy. There are several treatment planning systems (TPS) that can generate IMRT plans. These plans may show different inhomogeneity indices to the planning target volume (PTV) and integral dose to organs at risk (OAR). In this study, we compared clinical cases covering different anatomical treatment sites, including head and neck, brain, lung, prostate, pelvis, and cranio-spinal axis. Two treatment plans were developed for each case using Pinnacle3 and helical tomotherapy (HT) TPS. The inhomogeneity index of the PTV and the non-tumor integral dose (NTID) were calculated and compared for each case. Despite the difference in the number of effective beams, in several cases, NTID did not increase from HT as compared to the step-and-shoot delivery method. Six helical tomotherapy treatment plans for different treatment sites have been analyzed and compared against corresponding step-and-shoot plans generated with the Pinnacle3 planning system. Results show that HT may produce plans with smaller integral doses to healthy organs, and fairly homogeneous doses to the target as compared to linac-based step-and-shoot IMRT planning in special treatment site such as cranio-spinal.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18674686</pmid><doi>10.1016/j.meddos.2007.11.001</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0958-3947 |
| ispartof | Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 2008, Vol.33 (3), p.215-221 |
| issn | 0958-3947 1873-4022 |
| language | eng |
| recordid | cdi_osti_scitechconnect_21140789 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Aged BEAMS Body Burden BRAIN Brain Neoplasms - radiotherapy CARCINOMAS COMPUTERIZED TOMOGRAPHY CT-GUIDED RADIOTHERAPY Decision Support Systems, Clinical Dose-Response Relationship, Radiation Female HEAD Head and Neck Neoplasms - radiotherapy Hematology, Oncology and Palliative Medicine Humans IMRT Inhomogeneity index Integral dose INTEGRAL DOSES LINEAR ACCELERATORS Lung Neoplasms - radiotherapy LUNGS Male Middle Aged NECK Pelvic Neoplasms - radiotherapy PELVIS PROSTATE Prostatic Neoplasms - radiotherapy Radiation Tolerance Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiology Information Systems Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - methods Relative Biological Effectiveness Spinal Neoplasms - radiotherapy Tomography, Spiral Computed Tomotherapy Weights and Measures |
| title | Comparison of IMRT Treatment Plans Between Linac and Helical Tomotherapy Based on Integral Dose and Inhomogeneity Index |
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