Small Molecular Inhibitor of Transforming Growth Factor-{beta} Protects Against Development of Radiation-Induced Lung Injury

Purpose: To determine whether an anti-transforming growth factor-{beta} (TGF-{beta}) type 1 receptor inhibitor (SM16) can prevent radiation-induced lung injury. Methods and Materials: One fraction of 28 Gy or sham radiotherapy (RT) was administered to the right hemithorax of Sprague-Dawley rats. SM1...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2008-07, Vol.71 (3)
Hauptverfasser:	Anscher, Mitchell S., Thrasher, Bradley, Zgonjanin, Larisa, Rabbani, Zahid N., Corbley, Michael J., Fu Kai, Sun Lihong, Lee, W.-C., Ling, Leona E., Vujaskovic, Zeljko
Format:	Artikel
Sprache:	eng
Schlagworte:	FIBROSIS GROWTH FACTORS INFLAMMATION INJURIES LUNGS MACROPHAGES RADIATION DOSES RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY RATS RECEPTORS RESPIRATION TOXICITY
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