Delayed Effects of Whole Brain Radiotherapy in Germ Cell Tumor Patients With Central Nervous System Metastases

Purpose Central nervous system (CNS) metastases are uncommon in patients with germ cell tumors, with an incidence of 2–3%. CNS metastases have been managed with whole brain radiotherapy (WBRT) and concomitant cisplatin-based combination chemotherapy. Our previous study did not observe serious CNS to...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2008-04, Vol.70 (5), p.1361-1364
Hauptverfasser:	Doyle, Danielle M., M.D, Einhorn, Lawrence H., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use ATROPHY BRAIN Brain - drug effects Brain - radiation effects Brain metastasis Brain Neoplasms - blood Brain Neoplasms - drug therapy Brain Neoplasms - radiotherapy Brain Neoplasms - secondary CARCINOMAS CHEMOTHERAPY Choriocarcinoma - blood Choriocarcinoma - drug therapy Choriocarcinoma - radiotherapy Choriocarcinoma - secondary Chorionic Gonadotropin - blood Cisplatin - administration & dosage Combined Modality Therapy - adverse effects Combined Modality Therapy - methods Cranial Irradiation - adverse effects DIAGNOSIS Fatal Outcome Germ cell tumor GERM CELLS HEAD Hematology, Oncology and Palliative Medicine Humans Leukoencephalopathy, Progressive Multifocal - etiology Lung Neoplasms - secondary Male METASTASES Neoplasm Proteins - blood Neoplasms, Germ Cell and Embryonal - blood Neoplasms, Germ Cell and Embryonal - drug therapy Neoplasms, Germ Cell and Embryonal - radiotherapy Neoplasms, Germ Cell and Embryonal - secondary NERVOUS SYSTEM DISEASES PATIENTS Radiation encephalopathy Radiation Injuries - complications Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Salvage Therapy - methods Stem Cell Transplantation STEROIDS SURGERY SYMPTOMS Testicular Neoplasms - drug therapy Time Factors TOXICITY Whole brain radiotherapy
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