Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure

Recently, there have been increasing reports that nano-sized component of particulate matter can reach the brain and may be associated with neurodegenerative diseases. Previously, our laboratory has studied the effect of intranasal instillation of nano-sized carbon black (CB) (14 nm and 95 nm) on br...

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Veröffentlicht in:	Toxicology and applied pharmacology 2008-01, Vol.226 (2), p.192-198
Hauptverfasser:	Tin-Tin-Win-Shwe, Mitsushima, Dai, Yamamoto, Shoji, Fukushima, Atsushi, Funabashi, Toshiya, Kobayashi, Takahiro, Fujimaki, Hidekazu
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Air Pollutants - toxicity Animals BACTERIA Biological and medical sciences CARBON BLACK CELL WALL Chromatography, High Pressure Liquid Cytokines Cytokines - genetics Cytokines - metabolism gamma-Aminobutyric Acid - metabolism Glutamic Acid - biosynthesis GLYCINE Glycine - biosynthesis HIPPOCAMPUS IN VIVO Lipopolysaccharides - toxicity LYMPHOKINES Male Medical sciences MICE Mice, Inbred BALB C Microdialysis Nanoparticle Nanoparticles - toxicity NANOSTRUCTURES NERVOUS SYSTEM DISEASES Neurotransmitters Olfactory bulb Olfactory Bulb - drug effects Olfactory Bulb - metabolism OLFACTORY BULBS POLYMERASE CHAIN REACTION Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis SINGLE INTAKE Soot - administration & dosage Soot - toxicity TAURINE Taurine - metabolism Teichoic Acids - toxicity Toxicology
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