Undecylprodigiosin selectively induces apoptosis in human breast carcinoma cells independent of p53

Undecylprodigiosin (UP) is a bacterial bioactive metabolite produced by Streptomyces and Serratia. In this study, we explored the anticancer effect of UP. Human breast carcinoma cell lines BT-20, MCF-7, MDA-MB-231 and T47D and one nonmalignant human breast epithelial cell line, MCF-10A, were tested...

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Veröffentlicht in:	Toxicology and applied pharmacology 2007-12, Vol.225 (3), p.318-328
Hauptverfasser:	Ho, Tsing-Fen, Ma, Chieh-Ju, Lu, Chien-Hsing, Tsai, Yo-Ting, Wei, Yu-Hong, Chang, Jo-Shu, Lai, Jun-Kai, Cheuh, Pin-Ju, Yeh, Chi-Tai, Tang, Pin-Chi, Tsai Chang, Jinghua, Ko, Jiunn-Liang, Liu, Fu-Shing, Yen, Hungchen E., Chang, Chia-Che
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ADP Annexin A5 - drug effects Annexin A5 - metabolism Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology APOPTOSIS Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Bcl-2 family Bcl-2-Like Protein 11 bcl-X Protein - drug effects bcl-X Protein - metabolism Biological and medical sciences BORON CHLORIDES Breast cancer Breast Neoplasms - drug therapy CARCINOMAS Caspase 9 - drug effects Caspase 9 - metabolism Cell Line, Tumor Dose-Response Relationship, Drug Female Gynecology. Andrology. Obstetrics Humans In Situ Nick-End Labeling Inhibitor of Apoptosis Proteins KETONES Mammary gland diseases MAMMARY GLANDS Medical sciences Membrane Proteins - metabolism Microtubule-Associated Proteins - drug effects Microtubule-Associated Proteins - metabolism Myeloid Cell Leukemia Sequence 1 Protein Neoplasm Proteins - drug effects Neoplasm Proteins - metabolism p53 Poly (ADP-ribose) polymerase (PARP) Poly(ADP-ribose) Polymerases - drug effects Poly(ADP-ribose) Polymerases - metabolism POLYMERASES Prodigiosin - administration & dosage Prodigiosin - analogs & derivatives Prodigiosin - pharmacology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism RIBOSE RNA SERRATIA Serratia marcescens - chemistry STREPTOMYCES TETRAZOLIUM TIME DEPENDENCE Time Factors TOXICITY Toxicology Tumor Suppressor Protein p53 - drug effects Tumor Suppressor Protein p53 - metabolism Tumors Undecylprodigiosin (UP) X-Linked Inhibitor of Apoptosis Protein - drug effects X-Linked Inhibitor of Apoptosis Protein - metabolism z-VAD.fmk
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