Population differences in the human arsenic (+ 3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method
Arsenic poisoning from drinking groundwater is a serious problem, particularly in developing Asian countries. Human arsenic (+ 3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. Recently, a single nucleotide polymorphism (SNPs; rs17885947, M287T (T860C)) i...
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| Veröffentlicht in: | Toxicology and applied pharmacology 2007-12, Vol.225 (3), p.251-254 |
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| creator | Fujihara, Junko Kunito, Takashi Agusa, Tetsuro Yasuda, Toshihiro Iida, Reiko Fujii, Yoshimi Takeshita, Haruo |
| description | Arsenic poisoning from drinking groundwater is a serious problem, particularly in developing Asian countries. Human arsenic (+
3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. Recently, a single nucleotide polymorphism (SNPs; rs17885947, M287T (T860C)) in the AS3MT gene was shown to be related to enzyme activity and considered to be related to genetic susceptibility to arsenic. In the present study, a useful genotyping method for M287T was developed using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique. Applying this method, the genotype distribution of M287T in Ovambo (
n
=
185), Turkish (
n
=
191), Mongolian (
n
=
233), Korean (
n
=
200), and Japanese (
n
=
370) populations were investigated. The mutation frequencies in Asian populations were relatively lower than those of African and Caucasian populations, including those from previous studies: the frequencies of mutation in the Mongolian, Korean, and Japanese populations were 0.040, 0.010, and 0.010, respectively. In the course of this study, a PCR-based genotyping method that is inexpensive and does not require specialized equipment was developed. This method could be applied to a large number of residents at risk for arsenic poisoning. |
| doi_str_mv | 10.1016/j.taap.2007.08.010 |
| format | Article |
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3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. Recently, a single nucleotide polymorphism (SNPs; rs17885947, M287T (T860C)) in the AS3MT gene was shown to be related to enzyme activity and considered to be related to genetic susceptibility to arsenic. In the present study, a useful genotyping method for M287T was developed using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique. Applying this method, the genotype distribution of M287T in Ovambo (
n
=
185), Turkish (
n
=
191), Mongolian (
n
=
233), Korean (
n
=
200), and Japanese (
n
=
370) populations were investigated. The mutation frequencies in Asian populations were relatively lower than those of African and Caucasian populations, including those from previous studies: the frequencies of mutation in the Mongolian, Korean, and Japanese populations were 0.040, 0.010, and 0.010, respectively. In the course of this study, a PCR-based genotyping method that is inexpensive and does not require specialized equipment was developed. This method could be applied to a large number of residents at risk for arsenic poisoning.</description><identifier>ISSN: 0041-008X</identifier><identifier>EISSN: 1096-0333</identifier><identifier>DOI: 10.1016/j.taap.2007.08.010</identifier><identifier>PMID: 17889916</identifier><identifier>CODEN: TXAPA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; African Continental Ancestry Group - genetics ; ARSENIC ; Arsenic - metabolism ; Arsenic Poisoning - ethnology ; Arsenic Poisoning - genetics ; Arsenic Poisoning - metabolism ; AS3MT ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Chemical and industrial products toxicology. Toxic occupational diseases ; ENZYME ACTIVITY ; European Continental Ancestry Group - genetics ; Gene Frequency ; GENES ; Genotype ; Genotyping method ; GROUND WATER ; Humans ; Japan ; Korea ; Medical sciences ; Metals and various inorganic compounds ; METHYLATION ; Methyltransferases - genetics ; Mongolia ; Mutation ; MUTATION FREQUENCY ; Namibia ; NUCLEOTIDES ; PCR-RFLP ; POISONING ; POLYMERASE CHAIN REACTION ; Polymerase Chain Reaction - methods ; Polymorphism, Restriction Fragment Length ; Single nucleotide polymorphism (SNP) ; Toxicology ; Tumors ; TURKEY ; Water Pollutants, Chemical - metabolism ; Water Pollutants, Chemical - poisoning ; Worldwide populations</subject><ispartof>Toxicology and applied pharmacology, 2007-12, Vol.225 (3), p.251-254</ispartof><rights>2007 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-c7d220dc1cd5e2687210e4b4fa3df6ef973a283552d70e7298f5180a9214a3853</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.taap.2007.08.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19913131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17889916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21077872$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujihara, Junko</creatorcontrib><creatorcontrib>Kunito, Takashi</creatorcontrib><creatorcontrib>Agusa, Tetsuro</creatorcontrib><creatorcontrib>Yasuda, Toshihiro</creatorcontrib><creatorcontrib>Iida, Reiko</creatorcontrib><creatorcontrib>Fujii, Yoshimi</creatorcontrib><creatorcontrib>Takeshita, Haruo</creatorcontrib><title>Population differences in the human arsenic (+ 3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method</title><title>Toxicology and applied pharmacology</title><addtitle>Toxicol Appl Pharmacol</addtitle><description>Arsenic poisoning from drinking groundwater is a serious problem, particularly in developing Asian countries. Human arsenic (+
3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. Recently, a single nucleotide polymorphism (SNPs; rs17885947, M287T (T860C)) in the AS3MT gene was shown to be related to enzyme activity and considered to be related to genetic susceptibility to arsenic. In the present study, a useful genotyping method for M287T was developed using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique. Applying this method, the genotype distribution of M287T in Ovambo (
n
=
185), Turkish (
n
=
191), Mongolian (
n
=
233), Korean (
n
=
200), and Japanese (
n
=
370) populations were investigated. The mutation frequencies in Asian populations were relatively lower than those of African and Caucasian populations, including those from previous studies: the frequencies of mutation in the Mongolian, Korean, and Japanese populations were 0.040, 0.010, and 0.010, respectively. In the course of this study, a PCR-based genotyping method that is inexpensive and does not require specialized equipment was developed. This method could be applied to a large number of residents at risk for arsenic poisoning.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>African Continental Ancestry Group - genetics</subject><subject>ARSENIC</subject><subject>Arsenic - metabolism</subject><subject>Arsenic Poisoning - ethnology</subject><subject>Arsenic Poisoning - genetics</subject><subject>Arsenic Poisoning - metabolism</subject><subject>AS3MT</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>ENZYME ACTIVITY</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Gene Frequency</subject><subject>GENES</subject><subject>Genotype</subject><subject>Genotyping method</subject><subject>GROUND WATER</subject><subject>Humans</subject><subject>Japan</subject><subject>Korea</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>METHYLATION</subject><subject>Methyltransferases - genetics</subject><subject>Mongolia</subject><subject>Mutation</subject><subject>MUTATION FREQUENCY</subject><subject>Namibia</subject><subject>NUCLEOTIDES</subject><subject>PCR-RFLP</subject><subject>POISONING</subject><subject>POLYMERASE CHAIN REACTION</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Single nucleotide polymorphism (SNP)</subject><subject>Toxicology</subject><subject>Tumors</subject><subject>TURKEY</subject><subject>Water Pollutants, Chemical - metabolism</subject><subject>Water Pollutants, Chemical - poisoning</subject><subject>Worldwide populations</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoTk_rC7iQgDjMIN3eJFVdKXAzDP7BiIIjuAvp5NZ0mqqkTFJiP4ZvbIpumJ1kcbP4zuHcewh5wWDNgG3e7tdZ63HNAZo1yDUweEQWDNrNCoQQj8kCoGIrAPnzjJyntAeAtqrYU3LGGinblm0W5O-3ME69zi54al3XYURvMFHnad4h3U2D9lTHhN4ZevmGChr-OHvkU9YZr-iAeXfoc9Q-FblOSC-vv4svd1f0Hj3SMfSHIcRx59JALWY0GS3dHuiUnL-fmZAP4_ydjYJ9Rp50uk_4_DSX5MeH93c3n1a3Xz9-vrm-XZka2rwyjeUcrGHG1sg3suEMsNpWnRa222DXNkJzKeqa2waw4a3saiZBt5xVWshaLMmro29I2alkXEm2M8H7ElAVs6YpnoW6OFJjDL8mTFkNLhnse-0xTEmxtuatkFUB-RE0MaQUsVNjdIOOB8VAzXWpvZrrUnNdCqQqdRXRy5P7tB3QPkhO_RTg9QnQyei-K0c2Lj1wBRLzW5J3Rw7LxX47jPNCc5PWxXkfG9z_cvwD25e0GA</recordid><startdate>20071215</startdate><enddate>20071215</enddate><creator>Fujihara, Junko</creator><creator>Kunito, Takashi</creator><creator>Agusa, Tetsuro</creator><creator>Yasuda, Toshihiro</creator><creator>Iida, Reiko</creator><creator>Fujii, Yoshimi</creator><creator>Takeshita, Haruo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>OTOTI</scope></search><sort><creationdate>20071215</creationdate><title>Population differences in the human arsenic (+ 3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method</title><author>Fujihara, Junko ; Kunito, Takashi ; Agusa, Tetsuro ; Yasuda, Toshihiro ; Iida, Reiko ; Fujii, Yoshimi ; Takeshita, Haruo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-c7d220dc1cd5e2687210e4b4fa3df6ef973a283552d70e7298f5180a9214a3853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>African Continental Ancestry Group - genetics</topic><topic>ARSENIC</topic><topic>Arsenic - metabolism</topic><topic>Arsenic Poisoning - ethnology</topic><topic>Arsenic Poisoning - genetics</topic><topic>Arsenic Poisoning - metabolism</topic><topic>AS3MT</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>ENZYME ACTIVITY</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Gene Frequency</topic><topic>GENES</topic><topic>Genotype</topic><topic>Genotyping method</topic><topic>GROUND WATER</topic><topic>Humans</topic><topic>Japan</topic><topic>Korea</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>METHYLATION</topic><topic>Methyltransferases - genetics</topic><topic>Mongolia</topic><topic>Mutation</topic><topic>MUTATION FREQUENCY</topic><topic>Namibia</topic><topic>NUCLEOTIDES</topic><topic>PCR-RFLP</topic><topic>POISONING</topic><topic>POLYMERASE CHAIN REACTION</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Single nucleotide polymorphism (SNP)</topic><topic>Toxicology</topic><topic>Tumors</topic><topic>TURKEY</topic><topic>Water Pollutants, Chemical - metabolism</topic><topic>Water Pollutants, Chemical - poisoning</topic><topic>Worldwide populations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujihara, Junko</creatorcontrib><creatorcontrib>Kunito, Takashi</creatorcontrib><creatorcontrib>Agusa, Tetsuro</creatorcontrib><creatorcontrib>Yasuda, Toshihiro</creatorcontrib><creatorcontrib>Iida, Reiko</creatorcontrib><creatorcontrib>Fujii, Yoshimi</creatorcontrib><creatorcontrib>Takeshita, Haruo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujihara, Junko</au><au>Kunito, Takashi</au><au>Agusa, Tetsuro</au><au>Yasuda, Toshihiro</au><au>Iida, Reiko</au><au>Fujii, Yoshimi</au><au>Takeshita, Haruo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Population differences in the human arsenic (+ 3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>2007-12-15</date><risdate>2007</risdate><volume>225</volume><issue>3</issue><spage>251</spage><epage>254</epage><pages>251-254</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><coden>TXAPA9</coden><abstract>Arsenic poisoning from drinking groundwater is a serious problem, particularly in developing Asian countries. Human arsenic (+
3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. Recently, a single nucleotide polymorphism (SNPs; rs17885947, M287T (T860C)) in the AS3MT gene was shown to be related to enzyme activity and considered to be related to genetic susceptibility to arsenic. In the present study, a useful genotyping method for M287T was developed using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique. Applying this method, the genotype distribution of M287T in Ovambo (
n
=
185), Turkish (
n
=
191), Mongolian (
n
=
233), Korean (
n
=
200), and Japanese (
n
=
370) populations were investigated. The mutation frequencies in Asian populations were relatively lower than those of African and Caucasian populations, including those from previous studies: the frequencies of mutation in the Mongolian, Korean, and Japanese populations were 0.040, 0.010, and 0.010, respectively. In the course of this study, a PCR-based genotyping method that is inexpensive and does not require specialized equipment was developed. This method could be applied to a large number of residents at risk for arsenic poisoning.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>17889916</pmid><doi>10.1016/j.taap.2007.08.010</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-008X |
| ispartof | Toxicology and applied pharmacology, 2007-12, Vol.225 (3), p.251-254 |
| issn | 0041-008X 1096-0333 |
| language | eng |
| recordid | cdi_osti_scitechconnect_21077872 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 60 APPLIED LIFE SCIENCES African Continental Ancestry Group - genetics ARSENIC Arsenic - metabolism Arsenic Poisoning - ethnology Arsenic Poisoning - genetics Arsenic Poisoning - metabolism AS3MT Asian Continental Ancestry Group - genetics Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chemical and industrial products toxicology. Toxic occupational diseases ENZYME ACTIVITY European Continental Ancestry Group - genetics Gene Frequency GENES Genotype Genotyping method GROUND WATER Humans Japan Korea Medical sciences Metals and various inorganic compounds METHYLATION Methyltransferases - genetics Mongolia Mutation MUTATION FREQUENCY Namibia NUCLEOTIDES PCR-RFLP POISONING POLYMERASE CHAIN REACTION Polymerase Chain Reaction - methods Polymorphism, Restriction Fragment Length Single nucleotide polymorphism (SNP) Toxicology Tumors TURKEY Water Pollutants, Chemical - metabolism Water Pollutants, Chemical - poisoning Worldwide populations |
| title | Population differences in the human arsenic (+ 3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method |
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