Drug safety evaluation through biomarker analysis—A toxicity study in the cynomolgus monkey using an antibody-cytotoxic conjugate against ovarian cancer

Antibody–cytotoxin conjugates are complex novel therapeutic agents whose toxicological properties are not presently well understood. The objective of this study was to identify serum biomarkers that correlate with MLN8866 (an Antibody-Cytotoxic Conjugate, mAb8866-CT) pathological events in monkeys a...

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Veröffentlicht in:	Toxicology and applied pharmacology 2007-10, Vol.224 (1), p.12-18
Hauptverfasser:	Hsieh, Frank Y., Tengstrand, Elizabeth, Lee, Ju-Whei, Li, Lily Y., Silverman, Lee, Riordan, Bill, Miwa, Gerald, Milton, Mark, Alden, Carl, Lee, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals ANTIBODIES Antibodies - toxicity Antibody Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - toxicity Area Under Curve Biological and medical sciences BIOLOGICAL MARKERS Biologics Biomarker Biomarkers BLOOD FORMATION BONE MARROW Chromatography, Liquid Cynomolgus Dose-Response Relationship, Drug DOSES DRUGS Female Female genital diseases Gynecology. Andrology. Obstetrics HEMATOLOGY Immunoconjugate Immunotoxins - pharmacokinetics Immunotoxins - toxicity INFUSION Macaca fascicularis Mass Spectrometry Medical sciences Models, Statistical MONKEYS MTD NEOPLASMS Ovarian Neoplasms - drug therapy PATHOLOGY Predictive toxicity SAFETY ANALYSIS Safety evaluation TOXICITY Toxicokinetics Toxicology Toxin TOXINS Tumors
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