TNF[alpha] acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-[kappa]B-dependent pathways

Tumor necrosis factor [alpha] (TNF[alpha]) enhances proliferation of chemically-induced mammary tumors and of T47D human cell line through not fully understood pathways. Here, we explored the intracellular signaling pathways triggered by TNF[alpha], the participation of TNF[alpha] receptor (TNFR) 1...

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