Myostatin signals through Pax7 to regulate satellite cell self-renewal

Myostatin, a Transforming Growth Factor-beta (TGF-β) super-family member, has previously been shown to negatively regulate satellite cell activation and self-renewal. However, to date the mechanism behind Myostatin function in satellite cell biology is not known. Here we show that Myostatin signals...

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Veröffentlicht in:	Experimental cell research 2008-01, Vol.314 (2), p.317-329
Hauptverfasser:	McFarlane, Craig, Hennebry, Alex, Thomas, Mark, Plummer, Erin, Ling, Nicholas, Sharma, Mridula, Kambadur, Ravi
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Cell Differentiation CELL PROLIFERATION Cells, Cultured Cellular biology ERK1/2 Gene expression GENE REGULATION GROWTH FACTORS INTRINSIC FACTOR Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Models, Biological Muscle Development MUSCLES Musculoskeletal system MyoD Myostatin Pax7 PAX7 Transcription Factor - metabolism Reserve cell Satellite cell Satellite Cells, Skeletal Muscle - metabolism Self-renewal Signal Transduction Transforming Growth Factor beta - metabolism
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