Induction of apoptosis by NORE1A in a manner dependent on its nuclear export

The RASSF family proteins were identified as tumor suppressors in a variety of human cancers, and evidenced distinct subcellular localization patterns among their subfamilies and isoforms. In this study, we showed that NORE1A was exported actively via its nuclear export signal (NES) in the C-terminu...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-03, Vol.368 (1), p.56-61
Hauptverfasser:	Park, Sang-Joon, Lee, Deresa, Choi, Cheol-Yong, Ryu, Si-Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Active Transport, Cell Nucleus Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism ALANINES Animals APOPTOSIS Cell death signaling pathway Cell Line Cercopithecus aethiops Cytoplasm - metabolism Gene Deletion Humans LYSINE Mice Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism MST1 MUTANTS NEOPLASMS NITRIC OXIDE NORE1A Nuclear export signal Nuclear localization signal Nucleocytoplasmic shuttling PROTEINS
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