Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes
Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-α and PPARγ. Auraptene induced up-regulation of adiponectin expression and increased the ratio...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2008-02, Vol.366 (1), p.219-225 |
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| creator | Kuroyanagi, Kayo Kang, Min-Sook Goto, Tsuyoshi Hirai, Shizuka Ohyama, Kana Kusudo, Tatsuya Yu, Rina Yano, Masamichi Sasaki, Takao Takahashi, Nobuyuki Kawada, Teruo |
| description | Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-α and PPARγ. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPARγ antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPARγ activations. The results indicate that auraptene activates PPARγ in adipocytes to control adipocytekines such as adiponectin and MCP-1 and suggest that the consumption of citrus fruits, which contain auraptene can lead to a partial prevention of lipid and glucose metabolism abnormalities. |
| doi_str_mv | 10.1016/j.bbrc.2007.11.119 |
| format | Article |
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In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-α and PPARγ. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPARγ antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPARγ activations. 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In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-α and PPARγ. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPARγ antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPARγ activations. 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Kang, Min-Sook ; Goto, Tsuyoshi ; Hirai, Shizuka ; Ohyama, Kana ; Kusudo, Tatsuya ; Yu, Rina ; Yano, Masamichi ; Sasaki, Takao ; Takahashi, Nobuyuki ; Kawada, Teruo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-8fe6eb623275f76f8b3a5ed9ea603367bd9d50ac02ebb6dd4a4438131f753b6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>3T3-L1 Cells</topic><topic>60 APPLIED LIFE SCIENCES</topic><topic>Adipocyte</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Adiponectine</topic><topic>Animals</topic><topic>Auraptene</topic><topic>Chemokine CCL2 - metabolism</topic><topic>CITRUS</topic><topic>Citrus - metabolism</topic><topic>Coumarins - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>FRUITS</topic><topic>GENE REGULATION</topic><topic>GLUCOSE</topic><topic>INFLAMMATION</topic><topic>LIGANDS</topic><topic>LIPIDS</topic><topic>LUCIFERASE</topic><topic>MCP-1</topic><topic>Metabolic syndrome</topic><topic>METABOLISM</topic><topic>Mice</topic><topic>MOLECULAR WEIGHT</topic><topic>MONOCYTES</topic><topic>Peroxisome Proliferator-Activated Receptors - agonists</topic><topic>Plant Extracts - administration & dosage</topic><topic>PPAR</topic><topic>RECEPTORS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuroyanagi, Kayo</creatorcontrib><creatorcontrib>Kang, Min-Sook</creatorcontrib><creatorcontrib>Goto, Tsuyoshi</creatorcontrib><creatorcontrib>Hirai, Shizuka</creatorcontrib><creatorcontrib>Ohyama, Kana</creatorcontrib><creatorcontrib>Kusudo, Tatsuya</creatorcontrib><creatorcontrib>Yu, Rina</creatorcontrib><creatorcontrib>Yano, Masamichi</creatorcontrib><creatorcontrib>Sasaki, Takao</creatorcontrib><creatorcontrib>Takahashi, Nobuyuki</creatorcontrib><creatorcontrib>Kawada, Teruo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuroyanagi, Kayo</au><au>Kang, Min-Sook</au><au>Goto, Tsuyoshi</au><au>Hirai, Shizuka</au><au>Ohyama, Kana</au><au>Kusudo, Tatsuya</au><au>Yu, Rina</au><au>Yano, Masamichi</au><au>Sasaki, Takao</au><au>Takahashi, Nobuyuki</au><au>Kawada, Teruo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>366</volume><issue>1</issue><spage>219</spage><epage>225</epage><pages>219-225</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-α and PPARγ. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPARγ antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPARγ activations. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3T3-L1 Cells 60 APPLIED LIFE SCIENCES Adipocyte Adipocytes - drug effects Adipocytes - metabolism Adiponectine Animals Auraptene Chemokine CCL2 - metabolism CITRUS Citrus - metabolism Coumarins - administration & dosage Dose-Response Relationship, Drug FRUITS GENE REGULATION GLUCOSE INFLAMMATION LIGANDS LIPIDS LUCIFERASE MCP-1 Metabolic syndrome METABOLISM Mice MOLECULAR WEIGHT MONOCYTES Peroxisome Proliferator-Activated Receptors - agonists Plant Extracts - administration & dosage PPAR RECEPTORS |
| title | Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes |
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