Universal Survival Curve and Single Fraction Equivalent Dose: Useful Tools in Understanding Potency of Ablative Radiotherapy

Purpose Overprediction of the potency and toxicity of high-dose ablative radiotherapy such as stereotactic body radiotherapy (SBRT) by the linear quadratic (LQ) model led to many clinicians' hesitating to adopt this efficacious and well-tolerated therapeutic option. The aim of this study was to...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2008-03, Vol.70 (3), p.847-852
Hauptverfasser:	Park, Clint, M.D. M.S, Papiez, Lech, Ph.D, Zhang, Shichuan, M.D., Ph.D, Story, Michael, Ph.D, Timmerman, Robert D., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	APPROXIMATIONS Biologically effective dose Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy CARCINOMAS Cell Line, Tumor Cell Survival DNA Damage DNA Repair DOSE EQUIVALENTS Dose Fractionation FRACTIONATED IRRADIATION Hematology, Oncology and Palliative Medicine Humans Linear Models Linear quadratic model Lung Neoplasms - pathology Lung Neoplasms - radiotherapy LUNGS Models, Biological RADIATION DOSES Radiobiology Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiosurgery RADIOTHERAPY Relative Biological Effectiveness Single fraction equivalent dose Stereotactic body radiotherapy SURVIVAL CURVES TOXICITY Universal survival curve
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