Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking
Induction chemotherapy and concurrent chemoradiation for responders or immediate surgery for non-responders is an effective treatment strategy head and neck squamous cell carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would be valuable in selecting patients for thera...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2007-01, Vol.69 (2), p.S109-S111 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Kumar, Bhavna, M.Sc Cordell, Kitrina G., D.D.S Lee, Julia S., M.S Prince, Mark E., M.D Tran, Huong H., M.D Wolf, Gregory T., M.D Urba, Susan G., M.D Worden, Francis P., M.D Chepeha, Douglas B., M.D Teknos, Theodoros N., M.D Eisbruch, Avraham, M.D Tsien, Christina I., M.D Taylor, Jeremy M.G., Ph.D D'Silva, Nisha J., B.D.S., M.S.D., Ph.D Yang, Kun, M.D Kurnit, David M., M.D., Ph.D Bradford, Carol R., M.D Carey, Thomas E., Ph.D |
| description | Induction chemotherapy and concurrent chemoradiation for responders or immediate surgery for non-responders is an effective treatment strategy head and neck squamous cell carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would be valuable in selecting patients for therapy. In this study, the presence and titer of high risk human papilloma virus (HPV) and expression of epidermal growth factor receptor (EGFR) in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial. HPV16 copy number was positively associated with response to therapy and with overall and disease specific survival, whereas EGFR expression, current or former smoking behavior, and female gender (in this cohort) were associated with poor response and poor survival in multivariate analysis. Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile. |
| doi_str_mv | 10.1016/j.ijrobp.2007.05.072 |
| format | Article |
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Biomarkers that predict outcome would be valuable in selecting patients for therapy. In this study, the presence and titer of high risk human papilloma virus (HPV) and expression of epidermal growth factor receptor (EGFR) in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial. HPV16 copy number was positively associated with response to therapy and with overall and disease specific survival, whereas EGFR expression, current or former smoking behavior, and female gender (in this cohort) were associated with poor response and poor survival in multivariate analysis. Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2007.05.072</identifier><identifier>PMID: 17848274</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>BIOLOGICAL MARKERS ; BIOPSY ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - therapy ; Carcinoma, Squamous Cell - virology ; CARCINOMAS ; Chemoradiation ; CHEMOTHERAPY ; CLINICAL TRIALS ; Epidermal growth factor receptor ; Female ; GROWTH FACTORS ; HEAD ; HEALTH HAZARDS ; Hematology, Oncology and Palliative Medicine ; High risk human papillomavirus ; Human papillomavirus ; Human papillomavirus 16 ; Human papillomavirus 16 - isolation & purification ; Humans ; LARYNX ; LYMPHATIC SYSTEM ; Male ; Middle Aged ; NECK ; Neoplasm Proteins - metabolism ; Organ sparing clinical trial ; Oropharyngeal Neoplasms - metabolism ; Oropharyngeal Neoplasms - therapy ; Oropharyngeal Neoplasms - virology ; PATIENTS ; PHARYNX ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Receptor, Epidermal Growth Factor - metabolism ; RECEPTORS ; Sex Factors ; Smoking - adverse effects ; SURGERY ; Survival Analysis ; Tonsil cancer ; Treatment Outcome ; VIRUSES</subject><ispartof>International journal of radiation oncology, biology, physics, 2007-01, Vol.69 (2), p.S109-S111</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-105bef946ee212c1863806467aa8812308f1a77c75c3cd0ba128dbe2952668163</citedby><cites>FETCH-LOGICAL-c520t-105bef946ee212c1863806467aa8812308f1a77c75c3cd0ba128dbe2952668163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2007.05.072$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17848274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21036282$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Bhavna, M.Sc</creatorcontrib><creatorcontrib>Cordell, Kitrina G., D.D.S</creatorcontrib><creatorcontrib>Lee, Julia S., M.S</creatorcontrib><creatorcontrib>Prince, Mark E., M.D</creatorcontrib><creatorcontrib>Tran, Huong H., M.D</creatorcontrib><creatorcontrib>Wolf, Gregory T., M.D</creatorcontrib><creatorcontrib>Urba, Susan G., M.D</creatorcontrib><creatorcontrib>Worden, Francis P., M.D</creatorcontrib><creatorcontrib>Chepeha, Douglas B., M.D</creatorcontrib><creatorcontrib>Teknos, Theodoros N., M.D</creatorcontrib><creatorcontrib>Eisbruch, Avraham, M.D</creatorcontrib><creatorcontrib>Tsien, Christina I., M.D</creatorcontrib><creatorcontrib>Taylor, Jeremy M.G., Ph.D</creatorcontrib><creatorcontrib>D'Silva, Nisha J., B.D.S., M.S.D., Ph.D</creatorcontrib><creatorcontrib>Yang, Kun, M.D</creatorcontrib><creatorcontrib>Kurnit, David M., M.D., Ph.D</creatorcontrib><creatorcontrib>Bradford, Carol R., M.D</creatorcontrib><creatorcontrib>Carey, Thomas E., Ph.D</creatorcontrib><title>Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Induction chemotherapy and concurrent chemoradiation for responders or immediate surgery for non-responders is an effective treatment strategy head and neck squamous cell carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would be valuable in selecting patients for therapy. In this study, the presence and titer of high risk human papilloma virus (HPV) and expression of epidermal growth factor receptor (EGFR) in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial. HPV16 copy number was positively associated with response to therapy and with overall and disease specific survival, whereas EGFR expression, current or former smoking behavior, and female gender (in this cohort) were associated with poor response and poor survival in multivariate analysis. Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile.</description><subject>BIOLOGICAL MARKERS</subject><subject>BIOPSY</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>CARCINOMAS</subject><subject>Chemoradiation</subject><subject>CHEMOTHERAPY</subject><subject>CLINICAL TRIALS</subject><subject>Epidermal growth factor receptor</subject><subject>Female</subject><subject>GROWTH FACTORS</subject><subject>HEAD</subject><subject>HEALTH HAZARDS</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>High risk human papillomavirus</subject><subject>Human papillomavirus</subject><subject>Human papillomavirus 16</subject><subject>Human papillomavirus 16 - isolation & purification</subject><subject>Humans</subject><subject>LARYNX</subject><subject>LYMPHATIC SYSTEM</subject><subject>Male</subject><subject>Middle Aged</subject><subject>NECK</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Organ sparing clinical trial</subject><subject>Oropharyngeal Neoplasms - metabolism</subject><subject>Oropharyngeal Neoplasms - therapy</subject><subject>Oropharyngeal Neoplasms - virology</subject><subject>PATIENTS</subject><subject>PHARYNX</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><subject>RECEPTORS</subject><subject>Sex Factors</subject><subject>Smoking - adverse effects</subject><subject>SURGERY</subject><subject>Survival Analysis</subject><subject>Tonsil cancer</subject><subject>Treatment Outcome</subject><subject>VIRUSES</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFqGzEQhpfS0rhp36AUQaEn2x1pdyX5UnBN4gQCLklKexOydhzL3pW20m6KH6rvWG1sKPSSkwT65tfM_0-WvacwpUD5593U7oJft1MGIKZQTkGwF9mISjGb5GX582U2gpzDJE_wWfYmxh0AUCqK19kZFbKQTBSj7M8txta7iKTz5H6LQbcHol1FVn1nfIORWEdWwbdbHQ7uAXVNFtoZDGQekMxj9MbqDivyw3Zb8tX6Roc9hkiunan7yroHctU32pFvurV1nZ4fbejjmFy0tsLQJL1l8L9T7aU2nQ_kFg226TImS3SJGD91c9f4fdJ6m73a6Driu9N5nn2_vLhfXE1uVsvrxfxmYkoG3YRCucbNrOCIjDJDJc8l8IILraWkLAe5oVoII0qTmwrWmjJZrZHNSsa5pDw_zz4edX3srIrGdmi2xjuHplOMJl-ZZIn6dKTa4H_1GDvV2GiwrrVD30fFJePJZHgWZCBnMn9SLI6gCT7GgBvVBpscPSgKakhd7dQxdTWkrqBUKfVU9uGk368brP4VnWJOwJcjgMm0R4thmAlTjJUNw0iVt8_98L-Aqa2zRtd7PGDc-T64FIiiKjIF6m7YvGHxQADMeAn5X7pC1cY</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Kumar, Bhavna, M.Sc</creator><creator>Cordell, Kitrina G., D.D.S</creator><creator>Lee, Julia S., M.S</creator><creator>Prince, Mark E., M.D</creator><creator>Tran, Huong H., M.D</creator><creator>Wolf, Gregory T., M.D</creator><creator>Urba, Susan G., M.D</creator><creator>Worden, Francis P., M.D</creator><creator>Chepeha, Douglas B., M.D</creator><creator>Teknos, Theodoros N., M.D</creator><creator>Eisbruch, Avraham, M.D</creator><creator>Tsien, Christina I., M.D</creator><creator>Taylor, Jeremy M.G., Ph.D</creator><creator>D'Silva, Nisha J., B.D.S., M.S.D., Ph.D</creator><creator>Yang, Kun, M.D</creator><creator>Kurnit, David M., M.D., Ph.D</creator><creator>Bradford, Carol R., M.D</creator><creator>Carey, Thomas E., Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20070101</creationdate><title>Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking</title><author>Kumar, Bhavna, M.Sc ; Cordell, Kitrina G., D.D.S ; Lee, Julia S., M.S ; Prince, Mark E., M.D ; Tran, Huong H., M.D ; Wolf, Gregory T., M.D ; Urba, Susan G., M.D ; Worden, Francis P., M.D ; Chepeha, Douglas B., M.D ; Teknos, Theodoros N., M.D ; Eisbruch, Avraham, M.D ; Tsien, Christina I., M.D ; Taylor, Jeremy M.G., Ph.D ; D'Silva, Nisha J., B.D.S., M.S.D., Ph.D ; Yang, Kun, M.D ; Kurnit, David M., M.D., Ph.D ; Bradford, Carol R., M.D ; Carey, Thomas E., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-105bef946ee212c1863806467aa8812308f1a77c75c3cd0ba128dbe2952668163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>BIOLOGICAL MARKERS</topic><topic>BIOPSY</topic><topic>Carcinoma, Squamous Cell - 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metabolism</topic><topic>RECEPTORS</topic><topic>Sex Factors</topic><topic>Smoking - adverse effects</topic><topic>SURGERY</topic><topic>Survival Analysis</topic><topic>Tonsil cancer</topic><topic>Treatment Outcome</topic><topic>VIRUSES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Bhavna, M.Sc</creatorcontrib><creatorcontrib>Cordell, Kitrina G., D.D.S</creatorcontrib><creatorcontrib>Lee, Julia S., M.S</creatorcontrib><creatorcontrib>Prince, Mark E., M.D</creatorcontrib><creatorcontrib>Tran, Huong H., M.D</creatorcontrib><creatorcontrib>Wolf, Gregory T., M.D</creatorcontrib><creatorcontrib>Urba, Susan G., M.D</creatorcontrib><creatorcontrib>Worden, Francis P., M.D</creatorcontrib><creatorcontrib>Chepeha, Douglas B., M.D</creatorcontrib><creatorcontrib>Teknos, Theodoros N., M.D</creatorcontrib><creatorcontrib>Eisbruch, Avraham, M.D</creatorcontrib><creatorcontrib>Tsien, Christina I., M.D</creatorcontrib><creatorcontrib>Taylor, Jeremy M.G., Ph.D</creatorcontrib><creatorcontrib>D'Silva, Nisha J., B.D.S., M.S.D., Ph.D</creatorcontrib><creatorcontrib>Yang, Kun, M.D</creatorcontrib><creatorcontrib>Kurnit, David M., M.D., Ph.D</creatorcontrib><creatorcontrib>Bradford, Carol R., M.D</creatorcontrib><creatorcontrib>Carey, Thomas E., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - 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| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 2007-01, Vol.69 (2), p.S109-S111 |
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| language | eng |
| recordid | cdi_osti_scitechconnect_21036282 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | BIOLOGICAL MARKERS BIOPSY Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - therapy Carcinoma, Squamous Cell - virology CARCINOMAS Chemoradiation CHEMOTHERAPY CLINICAL TRIALS Epidermal growth factor receptor Female GROWTH FACTORS HEAD HEALTH HAZARDS Hematology, Oncology and Palliative Medicine High risk human papillomavirus Human papillomavirus Human papillomavirus 16 Human papillomavirus 16 - isolation & purification Humans LARYNX LYMPHATIC SYSTEM Male Middle Aged NECK Neoplasm Proteins - metabolism Organ sparing clinical trial Oropharyngeal Neoplasms - metabolism Oropharyngeal Neoplasms - therapy Oropharyngeal Neoplasms - virology PATIENTS PHARYNX Radiology RADIOLOGY AND NUCLEAR MEDICINE Receptor, Epidermal Growth Factor - metabolism RECEPTORS Sex Factors Smoking - adverse effects SURGERY Survival Analysis Tonsil cancer Treatment Outcome VIRUSES |
| title | Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking |
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