Trichostatin-A induces differential changes in histone protein dynamics and expression in HeLa cells

Trichostatin-A (TSA), a histone deacetylase (HDAC) inhibitor, results in enhanced acetylation of core histones thereby disrupting chromatin organization within living cells. We report on changes in chromatin organization and the resultant alteration in nuclear architecture following treatment with T...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-11, Vol.363 (2), p.263-268
Hauptverfasser:	Rao, Jyothsna, Bhattacharya, Dipanjan, Banerjee, Bidisha, Sarin, Apurva, Shivashankar, G.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACETYLATION Acetylation - drug effects ANISOTROPY BLEACHING CHROMATIN Chromatin - drug effects Chromatin - metabolism Chromatin assembly Confocal microscopy Dose-Response Relationship, Drug FCS FLUORESCENCE Fluorescence anisotropy FRAP Gene Expression Regulation - drug effects Gene Expression Regulation - physiology GENE REGULATION HDAC inhibitor HELA CELLS Histone acetylation Histone Deacetylase Inhibitors Histone Deacetylases - metabolism HISTONES Histones - metabolism Humans Hydroxamic Acids - administration & dosage PHOSPHORYLATION Phosphorylation - drug effects TRANSCRIPTION
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