Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells

Endostar, a novel recombinant human endostatin expressed and purified in Escherichia coli with an additional nine-amino acid sequence and forming another his-tag structure, was approved by the SFDA in 2005 for the treatment of non-small-cell lung cancer. But its mechanism of action has not been illu...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-09, Vol.361 (1), p.79-84
Hauptverfasser:	Ling, Yun, Yang, Yong, Lu, Na, You, Qi-dong, Wang, Sen, Gao, Ying, Chen, Yan, Guo, Qing-Long
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AMINO ACID SEQUENCE Angiogenesis Angiogenesis Inhibitors - pharmacology Animals Antineoplastic Agents - pharmacology CAPILLARIES Carcinoma, Lewis Lung - blood supply Carcinoma, Lewis Lung - pathology Cell Movement - drug effects Chick Embryo CHICKENS Endostar Endostatins - pharmacology Endothelial Cells - drug effects Endothelial Cells - physiology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects ESCHERICHIA COLI FETAL MEMBRANES Humans HUVEC IN VITRO In Vitro Techniques IN VIVO KDR/Flk-1 LUNGS Mice NEOPLASMS PHOSPHORYLATION Phosphorylation - drug effects RATS Signal Transduction - drug effects TYROSINE Tyrosine - metabolism Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - chemistry Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF VEINS
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